Specific antibody patterns over a two-year period after rubella immunization with RA 27/3 live attenuated vaccine

P. E. Valensin, G. M. Rossolini, M. G. Cusi, A. Zanchi, C. Cellesi, A. Rossolini

Research output: Contribution to journalArticlepeer-review

Abstract

Screening for rubella antibodies was carried out on 1557 schoolgirls aged 9-20. Of seronegative subjects 70% (442/631) were immunized with RA 27/3 rubella vaccine and some of the vaccinees underwent a serological and clinical follow-up over a two year period. Adverse reactions occurred in 27% of vaccinees, usually 1-2 weeks after immunization; late reactions were never observed. The vaccine-induced seroconversion rate evaluated at 4-5 weeks after immunization was 99.7%. Both one and two years after immunization the seropositivity rate of vaccinees was 100%. The maximum geometric mean antibody titre (GMT) was observed at 4-5 weeks after vaccination and a significant GMT decrease was evident on both the following annual controls. Specific antibody patterns in vaccinees were highly variable and in a small number of subjects a remarkable antibody titre decrease was noticed.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalVaccine
Volume5
Issue number4
DOIs
Publication statusPublished - 1987

Keywords

  • attenuated vaccine
  • field trial
  • Rubella

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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