Effetti specifici di ioni Cr sul DNA: confronto delle interazioni fra Cr e DNA purificato con le parallele interazioni che avvengono nella cellula vivente.

C. Balbi; D. Vecchio; P. Russo; S. Parodi; L. Santi

Effetti specifici di ioni Cr sul DNA: confronto delle interazioni fra Cr e DNA purificato con le parallele interazioni che avvengono nella cellula vivente.

Translated title of the contribution: Specific effects of Cr ions on DNA: a comparison between the interaction of CrIII with purified DNA and with DNA from cultured cells

C. Balbi, D. Vecchio, P. Russo, S. Parodi, L. Santi

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Affinity between CrIII and purified calf thymus DNA were studied by equilibrium dialysis at different pHs. Chromium was dosed by atomic spectrometry. This affinity was compared with Chromium-DNA affinity after treatment of living mammalian cells with CrVI and its intracellular reduction. Preliminary results seem to suggest that affinity is similar in both cases and not especially high (K approximately 10(5) 1/mole).

Translated title of the contribution	Specific effects of Cr ions on DNA: a comparison between the interaction of CrIII with purified DNA and with DNA from cultured cells
Original language	Italian
Pages (from-to)	1143-1148
Number of pages	6
Journal	Bollettino della Societa Italiana di Biologia Sperimentale
Volume	57
Issue number	10
Publication status	Published - May 30 1981

ASJC Scopus subject areas

Medicine(all)

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Effetti specifici di ioni Cr sul DNA : confronto delle interazioni fra Cr e DNA purificato con le parallele interazioni che avvengono nella cellula vivente. / Balbi, C.; Vecchio, D.; Russo, P. et al.

In: Bollettino della Societa Italiana di Biologia Sperimentale, Vol. 57, No. 10, 30.05.1981, p. 1143-1148.

Research output: Contribution to journal › Article › peer-review

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abstract = "Affinity between CrIII and purified calf thymus DNA were studied by equilibrium dialysis at different pHs. Chromium was dosed by atomic spectrometry. This affinity was compared with Chromium-DNA affinity after treatment of living mammalian cells with CrVI and its intracellular reduction. Preliminary results seem to suggest that affinity is similar in both cases and not especially high (K approximately 10(5) 1/mole).",

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AU - Russo, P.

AU - Parodi, S.

AU - Santi, L.

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AB - Affinity between CrIII and purified calf thymus DNA were studied by equilibrium dialysis at different pHs. Chromium was dosed by atomic spectrometry. This affinity was compared with Chromium-DNA affinity after treatment of living mammalian cells with CrVI and its intracellular reduction. Preliminary results seem to suggest that affinity is similar in both cases and not especially high (K approximately 10(5) 1/mole).

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Effetti specifici di ioni Cr sul DNA: confronto delle interazioni fra Cr e DNA purificato con le parallele interazioni che avvengono nella cellula vivente.

Abstract

ASJC Scopus subject areas

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