TY - JOUR
T1 - Specific HIV-1 integrase polymorphisms change their prevalence in untreated versus antiretroviral-treated HIV-1-infected patients, all naive to integrase inhibitors
AU - Ceccherini-Silberstein, Francesca
AU - Malet, Isabelle
AU - Fabeni, Lavinia
AU - Dimonte, Salvatore
AU - Svicher, Valentina
AU - D'Arrigo, Roberta
AU - Artese, Anna
AU - Costa, Giosuè
AU - Bono, Sara
AU - Alcaro, Stefano
AU - d'Arminio Monforte, Antonella
AU - Katlama, Christine
AU - Calvez, Vincent
AU - Antinori, Andrea
AU - Marcelin, Anne Genevieve
AU - Perno, Carlo Federico
PY - 2010/9/3
Y1 - 2010/9/3
N2 - Objectives: To define whether the prevalence of mutations associated with integrase inhibitor (INI) resistance is different in untreated versus antiretroviral-treated HIV-1-infected individuals (all INI naive). Methods: Gene sequences of the integrase (IN) and reverse transcriptase (RT) obtained from plasma samples of a well-defined cohort of 448 HIV-1-infected individuals (134 drug naive and 314 antiretroviral treated) were analysed. Docking simulations, using RT and IN models, were also performed. Results: Primary mutations and the majority of secondary mutations for raltegravir or elvitegravir were completely absent (or rarely found,
AB - Objectives: To define whether the prevalence of mutations associated with integrase inhibitor (INI) resistance is different in untreated versus antiretroviral-treated HIV-1-infected individuals (all INI naive). Methods: Gene sequences of the integrase (IN) and reverse transcriptase (RT) obtained from plasma samples of a well-defined cohort of 448 HIV-1-infected individuals (134 drug naive and 314 antiretroviral treated) were analysed. Docking simulations, using RT and IN models, were also performed. Results: Primary mutations and the majority of secondary mutations for raltegravir or elvitegravir were completely absent (or rarely found,
KW - Antiretroviral therapy
KW - Co-evolution
KW - HIV drug resistance
KW - Integrase
KW - Molecular docking
KW - Polymorphisms
KW - Reverse transcriptase
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U2 - 10.1093/jac/dkq326
DO - 10.1093/jac/dkq326
M3 - Article
C2 - 20817922
AN - SCOPUS:77957875432
VL - 65
SP - 2305
EP - 2318
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 11
M1 - dkq326
ER -