Specific IgE toward Allergenic molecules is a new prognostic marker in patients with sézary syndrome

Enrico Scala, Damiano Abeni, Paola Palazzo, Marina Liso, Debora Pomponi, Giuseppe Lombardo, Maria Cristina Picchio, Maria Grazia Narducci, Giandomenico Russo, Adriano Mari

Research output: Contribution to journalArticle

Abstract

Background: Sézary syndrome (SS) is the aggressive leukemic form of cutaneous T cell lymphoma characterized by erythroderma, the presence of a malignant circulating T memory cells with skin homing potential, and the ability to produce a variety of Th2 soluble factors, such as IL-4 and IL-5. We measured total and specific IgE in SS patients as a further parameter of a Th2-skewed immune system, and studied their clinical impact. Methods: Specific IgE production in a cohort of 55 SS patients was evaluated by the molecule-based ISAC microarray system. We then evaluated survival times and the hazard ratios in this cohort by Kaplan-Meier and Cox methods. Results: Twenty-four (43.6%) SS patients had specific IgE to both environmental and food allergens. For survival analysis, patients found positive to at least one allergen were defined as IgE+. By comparing IgE+ versus IgE-we found a significant difference in the median survival times, 2.9 versus 8.9 years (p <0.001). Conversely, no survival difference could be observed when total IgE levels were considered. IgE+ patients had higher levels of CD60+CD49-CD4+ T cells, which also represent another worse prognostic index recently identified. Conclusion: SS patients had specific IgE to both environmental and food allergens. IgE+ SS patients had a significant lower survival rate. High levels of CD60-CD49+CD4+ T cells associated with an IgE-phenotype allow the identification of a restricted group of long survivor SS patients. Therefore, specific measurement of IgE seems to be useful in discriminating survival.

Original languageEnglish
Pages (from-to)159-167
Number of pages9
JournalInternational Archives of Allergy and Immunology
Volume157
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Allergen microarray
  • CD60+CD49-CD4+ T cell phenotype
  • Cutaneous T cell lymphoma
  • Sézary syndrome
  • Specific IgE
  • Survival rate

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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