Specific LIF production in laryngeal cancer patients: evidence of suppressor activity exerted by adherent cells.

G. Cortesina, M. Bussi, B. Morra, F. Beatrice, G. P. Cavallo, V. Di Fortunato, E. Poggio, S. Rendine, A. Sartoris, S. Landolfo

Research output: Contribution to journalArticle

Abstract

The specific tumor-induced LIF production in 30 laryngeal cancer patients has been investigated before and after the removal of adherent cells to evaluate the existence of a suppressor activity. LIF production, after challenging lymphocytes with 3 M KCI autologous tumor extracts, was significant in 16 patients and showed a further significant increase after removal of adherent cells. A conversion to significance when the adherent cells were removed was shown in 6 patients, with no previous significant LIF production. These data suggest the existence of a suppressor activity exerted by adherent cells on LIF production in laryngeal cancer patients.

Original languageEnglish
Pages (from-to)497-502
Number of pages6
JournalTumori
Volume69
Issue number6
Publication statusPublished - Dec 31 1983

ASJC Scopus subject areas

  • Cancer Research

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    Cortesina, G., Bussi, M., Morra, B., Beatrice, F., Cavallo, G. P., Di Fortunato, V., Poggio, E., Rendine, S., Sartoris, A., & Landolfo, S. (1983). Specific LIF production in laryngeal cancer patients: evidence of suppressor activity exerted by adherent cells. Tumori, 69(6), 497-502.