Specific numerical processing impairment in ALS patients

Arianna Palmieri, Gianni Sorarù, Carla D'Ascenzo, Silvia Balestreri, Giorgio Arcara, Mario Ermani, Elena Pegoraro, Carlo Semenza

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The present study investigated for the first time numerical processing in sporadic amyotrophic lateral sclerosis (ALS) patients. Twenty-four non-demented patients affected by probable or definite ALS and 27 healthy controls underwent cognitive assessment. Numerical abilities (Number Comprehension, Number Transcoding, Arithmetic Fact retrieval, Calculation Skills and Arithmetic Principles) and neuropsychological functions were evaluated in accordance with Strong's consensus criteria. Clear group differences between the patients and controls were found in Multiplication Facts (Tables), Multiplication Approximation, and Multiplication Principles. These deficits were not statistically related to impairments of more general cognitive functioning. In conclusion, specific, previously unreported arithmetical deficits have been found in ALS patients. This particular impairment pattern could be indicative of damage to the cortico-subcortical circuits involved in some specific aspects of multiplication. Our findings could contribute to further delineate the profile of cognitive impairment in ALS.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Amyotrophic Lateral Sclerosis
Aptitude
Consensus

Keywords

  • ALS
  • Amyotrophic lateral sclerosis
  • Calculation
  • Numerical processing

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Palmieri, A., Sorarù, G., D'Ascenzo, C., Balestreri, S., Arcara, G., Ermani, M., ... Semenza, C. (2013). Specific numerical processing impairment in ALS patients. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14(1), 6-12. https://doi.org/10.3109/17482968.2012.719235

Specific numerical processing impairment in ALS patients. / Palmieri, Arianna; Sorarù, Gianni; D'Ascenzo, Carla; Balestreri, Silvia; Arcara, Giorgio; Ermani, Mario; Pegoraro, Elena; Semenza, Carlo.

In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 14, No. 1, 01.2013, p. 6-12.

Research output: Contribution to journalArticle

Palmieri, A, Sorarù, G, D'Ascenzo, C, Balestreri, S, Arcara, G, Ermani, M, Pegoraro, E & Semenza, C 2013, 'Specific numerical processing impairment in ALS patients', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 14, no. 1, pp. 6-12. https://doi.org/10.3109/17482968.2012.719235
Palmieri, Arianna ; Sorarù, Gianni ; D'Ascenzo, Carla ; Balestreri, Silvia ; Arcara, Giorgio ; Ermani, Mario ; Pegoraro, Elena ; Semenza, Carlo. / Specific numerical processing impairment in ALS patients. In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2013 ; Vol. 14, No. 1. pp. 6-12.
@article{3ed71782839e4267b342d0ccbdb99f35,
title = "Specific numerical processing impairment in ALS patients",
abstract = "The present study investigated for the first time numerical processing in sporadic amyotrophic lateral sclerosis (ALS) patients. Twenty-four non-demented patients affected by probable or definite ALS and 27 healthy controls underwent cognitive assessment. Numerical abilities (Number Comprehension, Number Transcoding, Arithmetic Fact retrieval, Calculation Skills and Arithmetic Principles) and neuropsychological functions were evaluated in accordance with Strong's consensus criteria. Clear group differences between the patients and controls were found in Multiplication Facts (Tables), Multiplication Approximation, and Multiplication Principles. These deficits were not statistically related to impairments of more general cognitive functioning. In conclusion, specific, previously unreported arithmetical deficits have been found in ALS patients. This particular impairment pattern could be indicative of damage to the cortico-subcortical circuits involved in some specific aspects of multiplication. Our findings could contribute to further delineate the profile of cognitive impairment in ALS.",
keywords = "ALS, Amyotrophic lateral sclerosis, Calculation, Numerical processing",
author = "Arianna Palmieri and Gianni Sorar{\`u} and Carla D'Ascenzo and Silvia Balestreri and Giorgio Arcara and Mario Ermani and Elena Pegoraro and Carlo Semenza",
year = "2013",
month = "1",
doi = "10.3109/17482968.2012.719235",
language = "English",
volume = "14",
pages = "6--12",
journal = "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration",
issn = "2167-8421",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Specific numerical processing impairment in ALS patients

AU - Palmieri, Arianna

AU - Sorarù, Gianni

AU - D'Ascenzo, Carla

AU - Balestreri, Silvia

AU - Arcara, Giorgio

AU - Ermani, Mario

AU - Pegoraro, Elena

AU - Semenza, Carlo

PY - 2013/1

Y1 - 2013/1

N2 - The present study investigated for the first time numerical processing in sporadic amyotrophic lateral sclerosis (ALS) patients. Twenty-four non-demented patients affected by probable or definite ALS and 27 healthy controls underwent cognitive assessment. Numerical abilities (Number Comprehension, Number Transcoding, Arithmetic Fact retrieval, Calculation Skills and Arithmetic Principles) and neuropsychological functions were evaluated in accordance with Strong's consensus criteria. Clear group differences between the patients and controls were found in Multiplication Facts (Tables), Multiplication Approximation, and Multiplication Principles. These deficits were not statistically related to impairments of more general cognitive functioning. In conclusion, specific, previously unreported arithmetical deficits have been found in ALS patients. This particular impairment pattern could be indicative of damage to the cortico-subcortical circuits involved in some specific aspects of multiplication. Our findings could contribute to further delineate the profile of cognitive impairment in ALS.

AB - The present study investigated for the first time numerical processing in sporadic amyotrophic lateral sclerosis (ALS) patients. Twenty-four non-demented patients affected by probable or definite ALS and 27 healthy controls underwent cognitive assessment. Numerical abilities (Number Comprehension, Number Transcoding, Arithmetic Fact retrieval, Calculation Skills and Arithmetic Principles) and neuropsychological functions were evaluated in accordance with Strong's consensus criteria. Clear group differences between the patients and controls were found in Multiplication Facts (Tables), Multiplication Approximation, and Multiplication Principles. These deficits were not statistically related to impairments of more general cognitive functioning. In conclusion, specific, previously unreported arithmetical deficits have been found in ALS patients. This particular impairment pattern could be indicative of damage to the cortico-subcortical circuits involved in some specific aspects of multiplication. Our findings could contribute to further delineate the profile of cognitive impairment in ALS.

KW - ALS

KW - Amyotrophic lateral sclerosis

KW - Calculation

KW - Numerical processing

UR - http://www.scopus.com/inward/record.url?scp=84875477965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875477965&partnerID=8YFLogxK

U2 - 10.3109/17482968.2012.719235

DO - 10.3109/17482968.2012.719235

M3 - Article

VL - 14

SP - 6

EP - 12

JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

SN - 2167-8421

IS - 1

ER -