Specific organic acids enhance the D-ribose productivity of a transketolase-defective Bacillus subtilis strain

Peter De Wulf, Wim Soetaert, Dieter Schwengers, Erick J. Vandamme

Research output: Contribution to journalArticlepeer-review

Abstract

When the transketolase-defective and D-ribose-producing Bacillus subtilis strain ATCC 21951 was cultured in a medium provided with certain organic acids, a significantly enhanced D-ribose titre was obtained, while the production of acetoin and 2,3-butanediol drastically decreased. Although the biochemical background of this phenomenon is not completely understood, it makes D-ribose synthesis more efficient and cheaper, the latter due to an easier recovery of D-ribose from the fermentation medium.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalJournal of Chemical Technology and Biotechnology
Volume70
Issue number3
DOIs
Publication statusPublished - Nov 1997

Keywords

  • Bacillus subtilis
  • D-ribose
  • Organic acid
  • Pentose phosphate cycle
  • Transketolase

ASJC Scopus subject areas

  • Biotechnology
  • Chemical Engineering(all)
  • Bioengineering
  • Chemistry(all)

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