Specific organic acids enhance the D-ribose productivity of a transketolase-defective Bacillus subtilis strain

Peter De Wulf; Wim Soetaert; Dieter Schwengers; Erick J. Vandamme

doi:10.1002/(SICI)1097-4660(199711)70:3<311::AID-JCTB758>3.0.CO;2-8

Specific organic acids enhance the D-ribose productivity of a transketolase-defective Bacillus subtilis strain

Peter De Wulf, Wim Soetaert, Dieter Schwengers, Erick J. Vandamme

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

When the transketolase-defective and D-ribose-producing Bacillus subtilis strain ATCC 21951 was cultured in a medium provided with certain organic acids, a significantly enhanced D-ribose titre was obtained, while the production of acetoin and 2,3-butanediol drastically decreased. Although the biochemical background of this phenomenon is not completely understood, it makes D-ribose synthesis more efficient and cheaper, the latter due to an easier recovery of D-ribose from the fermentation medium.

Original language	English
Pages (from-to)	311-315
Number of pages	5
Journal	Journal of Chemical Technology and Biotechnology
Volume	70
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1097-4660(199711)70:3<311::AID-JCTB758>3.0.CO;2-8
Publication status	Published - Nov 1997

Keywords

Bacillus subtilis
D-ribose
Organic acid
Pentose phosphate cycle
Transketolase

ASJC Scopus subject areas

Biotechnology
Chemical Engineering(all)
Bioengineering
Chemistry(all)

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10.1002/(SICI)1097-4660(199711)70:3<311::AID-JCTB758>3.0.CO;2-8

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abstract = "When the transketolase-defective and D-ribose-producing Bacillus subtilis strain ATCC 21951 was cultured in a medium provided with certain organic acids, a significantly enhanced D-ribose titre was obtained, while the production of acetoin and 2,3-butanediol drastically decreased. Although the biochemical background of this phenomenon is not completely understood, it makes D-ribose synthesis more efficient and cheaper, the latter due to an easier recovery of D-ribose from the fermentation medium.",

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AU - Schwengers, Dieter

AU - Vandamme, Erick J.

PY - 1997/11

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AB - When the transketolase-defective and D-ribose-producing Bacillus subtilis strain ATCC 21951 was cultured in a medium provided with certain organic acids, a significantly enhanced D-ribose titre was obtained, while the production of acetoin and 2,3-butanediol drastically decreased. Although the biochemical background of this phenomenon is not completely understood, it makes D-ribose synthesis more efficient and cheaper, the latter due to an easier recovery of D-ribose from the fermentation medium.

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KW - Organic acid

KW - Pentose phosphate cycle

KW - Transketolase

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Specific organic acids enhance the D-ribose productivity of a transketolase-defective Bacillus subtilis strain

Abstract

Keywords

ASJC Scopus subject areas

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