Specific protein profile in cerebrospinal fluid from HIV-1-positive cART-treated patients affected by neurological disorders

Valentina Zanin, Serena Delbue, Annalisa Marcuzzi, Eleonora Tavazzi, Rossella Del Savio, Sergio Crovella, Enrico Marchioni, Pasquale Ferrante, Manola Comar

Research output: Contribution to journalArticle

Abstract

Cytokines/chemokines are involved in the immune response of infections, including HIV-1. We defined the profile of 48 cytokines/chemokines in cerebrospinal fluid from 18 cART patients with chronic HIV-1 infection by Luminex technology. Nine patients were affected with leukoencephalopathies: five with John Cunningham virus (JCV) + progressive multifocal leukoencephalopathy (PML) and four with JCV-not determined leukoencephalopathy (NDLE). In addition, nine HIV-1-positive patients with no neurological signs (NND) and five HIV-1-negative patients affected with acute disseminated encephalomyelitis (ADEM) were enrolled. Ten cytokines (IL-15, IL-3, IL-16, IL-18, CTACK, GRO1, SCF, MCP-1, MIF, SDF) were highly expressed in HIV-1-positive patients while IL-1Ra and IL-17 were present at a lower level. In addition, the levels of IL-17, IL-9, FGF-basic, MIP-1β, and MCP-1 were significantly higher (p

Original languageEnglish
Pages (from-to)416-422
Number of pages7
JournalJournal of NeuroVirology
Volume18
Issue number5
DOIs
Publication statusPublished - Oct 2012

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Keywords

  • cART
  • Cytokines
  • HIV-1
  • Leukoencephalopathies

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

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