Specific recognition of cruciform DNA by nuclear protein HMGl

M. E. Bianchi, M. Beltrame, G. Paonessa

Research output: Contribution to journalArticlepeer-review

Abstract

Cruciform DNA, a non-double helix form of DNA, can be generated as an intermediate in genetic recombination as well as from palindromic sequences under the effect of supercoiling. Eukaryotic cells are equipped with a DNA-binding protein that selectively recognizes cruciform DNA. Biochemical and immunological data showed that this protein is HMGl, an evolutionary conserved, essential, and abundant component of the nucleus. The interaction with a ubiquitous protein to a critical role for cruciform DNA conformations.

Original languageEnglish
Pages (from-to)1056-1059
Number of pages4
JournalScience
Volume243
Issue number4894
Publication statusPublished - 1989

ASJC Scopus subject areas

  • General

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