Cruciform DNA, a non-double helix form of DNA, can be generated as an intermediate in genetic recombination as well as from palindromic sequences under the effect of supercoiling. Eukaryotic cells are equipped with a DNA-binding protein that selectively recognizes cruciform DNA. Biochemical and immunological data showed that this protein is HMGl, an evolutionary conserved, essential, and abundant component of the nucleus. The interaction with a ubiquitous protein to a critical role for cruciform DNA conformations.
|Number of pages||4|
|Publication status||Published - 1989|
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