SPECT, MRI and cognitive functions in multiple sclerosis

C. Pozzilli, D. Passafiume, S. Bernardi, P. Pantano, C. Incoccia, S. Bastianello, L. Bozzao, G. L. Lenzi, C. Fieschi

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Seventeen patients with relapsing remitting multiple sclerosis (MS) and mild physical disability had neuropsychological testing, magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT) using technetium 99m (99mTc) hexamethyl-propyleneamine oxime (HMPAO). Performance in verbal fluency, naming and memory testing appeared to be impaired in MS patients compared with 17 age- sex- and education-matched normal controls. Weighted periventricular and confluent lesion scores and the width of the third ventricle, proved to be the most sensitive MRI measures in differentiating more cognitively impaired patients from those who were relatively unimpaired. Ratios of regional to whole brain activity, measured by SPECT, showed significant reduction in the frontal lobes and in the left temporal lobe of MS patients. A relationship was found between left temporal abnormality in 99mTc-HMPAO uptake and deficit in verbal fluency and verbal memory. Finally, asymmetrical lobar activity indicated a predominant left rather than right temporo-parietal involvement.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume54
Issue number2
Publication statusPublished - 1991

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Single-Photon Emission-Computed Tomography
Cognition
Multiple Sclerosis
Magnetic Resonance Imaging
Oximes
Relapsing-Remitting Multiple Sclerosis
Third Ventricle
Sex Education
Technetium
Frontal Lobe
Temporal Lobe
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Pozzilli, C., Passafiume, D., Bernardi, S., Pantano, P., Incoccia, C., Bastianello, S., ... Fieschi, C. (1991). SPECT, MRI and cognitive functions in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 54(2), 110-115.

SPECT, MRI and cognitive functions in multiple sclerosis. / Pozzilli, C.; Passafiume, D.; Bernardi, S.; Pantano, P.; Incoccia, C.; Bastianello, S.; Bozzao, L.; Lenzi, G. L.; Fieschi, C.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 54, No. 2, 1991, p. 110-115.

Research output: Contribution to journalArticle

Pozzilli, C, Passafiume, D, Bernardi, S, Pantano, P, Incoccia, C, Bastianello, S, Bozzao, L, Lenzi, GL & Fieschi, C 1991, 'SPECT, MRI and cognitive functions in multiple sclerosis', Journal of Neurology, Neurosurgery and Psychiatry, vol. 54, no. 2, pp. 110-115.
Pozzilli, C. ; Passafiume, D. ; Bernardi, S. ; Pantano, P. ; Incoccia, C. ; Bastianello, S. ; Bozzao, L. ; Lenzi, G. L. ; Fieschi, C. / SPECT, MRI and cognitive functions in multiple sclerosis. In: Journal of Neurology, Neurosurgery and Psychiatry. 1991 ; Vol. 54, No. 2. pp. 110-115.
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