SPECT predictors of cognitive decline and alzheimer's disease in mild cognitive impairment

Flavio Nobili, Fabrizio De Carli, Giovanni B. Frisoni, Florence Portet, Frans Verhey, Guido Rodriguez, Anna Caroli, Jacques Touchon, Silvia Morbelli, Ugo P. Guerra, Barbara Dessi, Andrea Brugnolo, Pieter Jelle Visser

Research output: Contribution to journalArticlepeer-review


Baseline brain single photon emission computed tomography (SPECT) was evaluated in eighty subjects with mild cognitive impairment (MCI) who were followed for a mean of about two years, when twelve patients developed Alzheimer's disease (AD), nineteen showed memory decline (D), and forty-three had normal cognition assessment (stable: S) (six drop-out). Volumetric Regions of Interest (VROI) analysis was performed in six associative cortical areas in each hemisphere. ANOVA for repeated measures showed significant effects for both the group (S, D, and AD; p <0.004) and VROI (p <0.0001) factors, with significant group region interaction (p <0.01). At post-hoc comparison, hippocampal VROIs values were lower in AD than in D and S, while parietal VROIs values were lower in D and AD than in S. These four VROI significantly correlated with verbal delayed recall score at follow-up visit. Receiver operating characteristic (ROC) curves for the mean hippocampal VROI value showed 0.81 sensitivity with 0.86 specificity in separation of S+D from AD (p <0.0001), and 0.69 sensitivity with 0.75 specificity in separation of S from D+AD (p <0.0002). ROC curves for the mean parietal VROI value showed 0.62 sensitivity with 0.70 specificity in separation of S from D+AD (p <0.0002). Baseline SPECT can support outcome prediction in subjects with MCI.

Original languageEnglish
Pages (from-to)761-772
Number of pages12
JournalJournal of Alzheimer's Disease
Issue number4
Publication statusPublished - 2009


  • Alzheimer's disease
  • Amnestic MCI
  • Brain SPECT
  • Cognitive decline
  • Non-amnestic MCI
  • Subjective cognitive impairment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology
  • Medicine(all)


Dive into the research topics of 'SPECT predictors of cognitive decline and alzheimer's disease in mild cognitive impairment'. Together they form a unique fingerprint.

Cite this