Abstract
Baseline brain single photon emission computed tomography (SPECT) was evaluated in eighty subjects with mild cognitive impairment (MCI) who were followed for a mean of about two years, when twelve patients developed Alzheimer's disease (AD), nineteen showed memory decline (D), and forty-three had normal cognition assessment (stable: S) (six drop-out). Volumetric Regions of Interest (VROI) analysis was performed in six associative cortical areas in each hemisphere. ANOVA for repeated measures showed significant effects for both the group (S, D, and AD; p <0.004) and VROI (p <0.0001) factors, with significant group region interaction (p <0.01). At post-hoc comparison, hippocampal VROIs values were lower in AD than in D and S, while parietal VROIs values were lower in D and AD than in S. These four VROI significantly correlated with verbal delayed recall score at follow-up visit. Receiver operating characteristic (ROC) curves for the mean hippocampal VROI value showed 0.81 sensitivity with 0.86 specificity in separation of S+D from AD (p <0.0001), and 0.69 sensitivity with 0.75 specificity in separation of S from D+AD (p <0.0002). ROC curves for the mean parietal VROI value showed 0.62 sensitivity with 0.70 specificity in separation of S from D+AD (p <0.0002). Baseline SPECT can support outcome prediction in subjects with MCI.
| Original language | English |
|---|---|
| Pages (from-to) | 761-772 |
| Number of pages | 12 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2009 |
Fingerprint
Keywords
- Alzheimer's disease
- Amnestic MCI
- Brain SPECT
- Cognitive decline
- Non-amnestic MCI
- Subjective cognitive impairment
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology
- Medicine(all)
Cite this
SPECT predictors of cognitive decline and alzheimer's disease in mild cognitive impairment. / Nobili, Flavio; De Carli, Fabrizio; Frisoni, Giovanni B.; Portet, Florence; Verhey, Frans; Rodriguez, Guido; Caroli, Anna; Touchon, Jacques; Morbelli, Silvia; Guerra, Ugo P.; Dessi, Barbara; Brugnolo, Andrea; Visser, Pieter Jelle.
In: Journal of Alzheimer's Disease, Vol. 17, No. 4, 2009, p. 761-772.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SPECT predictors of cognitive decline and alzheimer's disease in mild cognitive impairment
AU - Nobili, Flavio
AU - De Carli, Fabrizio
AU - Frisoni, Giovanni B.
AU - Portet, Florence
AU - Verhey, Frans
AU - Rodriguez, Guido
AU - Caroli, Anna
AU - Touchon, Jacques
AU - Morbelli, Silvia
AU - Guerra, Ugo P.
AU - Dessi, Barbara
AU - Brugnolo, Andrea
AU - Visser, Pieter Jelle
PY - 2009
Y1 - 2009
N2 - Baseline brain single photon emission computed tomography (SPECT) was evaluated in eighty subjects with mild cognitive impairment (MCI) who were followed for a mean of about two years, when twelve patients developed Alzheimer's disease (AD), nineteen showed memory decline (D), and forty-three had normal cognition assessment (stable: S) (six drop-out). Volumetric Regions of Interest (VROI) analysis was performed in six associative cortical areas in each hemisphere. ANOVA for repeated measures showed significant effects for both the group (S, D, and AD; p <0.004) and VROI (p <0.0001) factors, with significant group region interaction (p <0.01). At post-hoc comparison, hippocampal VROIs values were lower in AD than in D and S, while parietal VROIs values were lower in D and AD than in S. These four VROI significantly correlated with verbal delayed recall score at follow-up visit. Receiver operating characteristic (ROC) curves for the mean hippocampal VROI value showed 0.81 sensitivity with 0.86 specificity in separation of S+D from AD (p <0.0001), and 0.69 sensitivity with 0.75 specificity in separation of S from D+AD (p <0.0002). ROC curves for the mean parietal VROI value showed 0.62 sensitivity with 0.70 specificity in separation of S from D+AD (p <0.0002). Baseline SPECT can support outcome prediction in subjects with MCI.
AB - Baseline brain single photon emission computed tomography (SPECT) was evaluated in eighty subjects with mild cognitive impairment (MCI) who were followed for a mean of about two years, when twelve patients developed Alzheimer's disease (AD), nineteen showed memory decline (D), and forty-three had normal cognition assessment (stable: S) (six drop-out). Volumetric Regions of Interest (VROI) analysis was performed in six associative cortical areas in each hemisphere. ANOVA for repeated measures showed significant effects for both the group (S, D, and AD; p <0.004) and VROI (p <0.0001) factors, with significant group region interaction (p <0.01). At post-hoc comparison, hippocampal VROIs values were lower in AD than in D and S, while parietal VROIs values were lower in D and AD than in S. These four VROI significantly correlated with verbal delayed recall score at follow-up visit. Receiver operating characteristic (ROC) curves for the mean hippocampal VROI value showed 0.81 sensitivity with 0.86 specificity in separation of S+D from AD (p <0.0001), and 0.69 sensitivity with 0.75 specificity in separation of S from D+AD (p <0.0002). ROC curves for the mean parietal VROI value showed 0.62 sensitivity with 0.70 specificity in separation of S from D+AD (p <0.0002). Baseline SPECT can support outcome prediction in subjects with MCI.
KW - Alzheimer's disease
KW - Amnestic MCI
KW - Brain SPECT
KW - Cognitive decline
KW - Non-amnestic MCI
KW - Subjective cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=68949164661&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68949164661&partnerID=8YFLogxK
U2 - 10.3233/JAD-2009-1091
DO - 10.3233/JAD-2009-1091
M3 - Article
C2 - 19542623
AN - SCOPUS:68949164661
VL - 17
SP - 761
EP - 772
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 4
ER -