SPECT radiopharmaceuticals for dementia

Claudio Guidotti, Daniela Farioli, Maria Chiara Gaeta, Elisabetta Giovannini, Patrizia Lazzeri, Martina Meniconi, Andrea Ciarmiello

Research output: Contribution to journalArticle

Abstract

Over the last decade the interest towards functional neuroimaging has gradually increased, especially in the field of neurodegenerative diseases. At present, diagnosis of dementia is mostly clinical. Numerous modalities of neuroimaging are today available, each of them allowing a different aspect of neurodegeneration to be investigated. Although during the last period many have predicted a forthcoming disappearance of SPECT imaging in favour of the PET imaging, many new radiotracers SPECT, dual-SPECT tracers techniques and receptor targeting designed radiopharmaceuticals are currently at study. Besides, last decade has also assisted to the development of new SPECT imaging systems, most of them integrated with other imaging modalities (MRI, CT, ultrasound techniques), granting improved imaging capabilities. All these improved conditions, especially appealing for the neuroimaging, together with the new radiopharmaceuticals in development may renovate the interest for SPECT clinical applications.

Original languageEnglish
Pages (from-to)192-207
Number of pages16
JournalCurrent Radiopharmaceuticals
Volume6
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • 99mTc
  • Dementia
  • Functional imaging
  • Neuroimaging
  • Radiopharmaceuticals
  • SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pharmacology

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    Guidotti, C., Farioli, D., Gaeta, M. C., Giovannini, E., Lazzeri, P., Meniconi, M., & Ciarmiello, A. (2013). SPECT radiopharmaceuticals for dementia. Current Radiopharmaceuticals, 6(4), 192-207. https://doi.org/10.2174/1874471006666131217112006