Spectral analysis of short-term heart rate variability in diabetic patients

Giancarlo Comi, Maria Grazia Natali Sora, Anna Bianchi, Bruno Bontempi, Paolo Gianoglio, Sergio Cerutti, Piero Micossi, Nicola Canal

Research output: Contribution to journalArticlepeer-review


Spectral analysis of short term R-R variability estimated by autoregressive modelling is a recently developed method for the evaluation of cardiovascular autonomic function. This new test also allows to study the interaction on heart rate variability of parasympathetic and sympathetic system. The sensitivity of the method for detection of cardiovascular autonomic neuropathy has been evaluated in a group of diabetic patients in comparison with the sensitivity of a battery of the most commonly used cardiovascular autonomic tests (deep-breathing, lying-to-standing, Valsalva Manoeuvre, postural hypotension and hand grip). Spectral analysis of heart rate variability resulted in a very sensitive method for early detection of diabetic autonomic neuropathy, about one-fourth of diabetic patients with normal traditional cardiovascular autonomic tests had abnormal results at spectral analysis. Both sympathetic and vagal control of heart rate resulted altered in diabetic autonomic neuropathy.

Original languageEnglish
JournalJournal of the Autonomic Nervous System
Issue numberSUPPL.
Publication statusPublished - 1990


  • Autonomic nervous system
  • Biological signals processing
  • Diabetic autonomic neuropathy
  • Heart rate variability

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Neuroscience(all)


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