Spectral-domain OCT in anti-VEGF treatment of myopic choroidal neovascularization

U. Introini, G. Casalino, G. Querques, A. T. Gimeno, F. Scotti, F. Bandello

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate changes in macular morphology due to myopic choroidal neovascularization (CNV), using spectral-domain optical coherence tomography (SD-OCT). Methods: In all, 22 eyes with recent-onset untreated CNV underwent 1 intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF), followed by a pro-re-nata regimen. SD-OCT was performed at baseline (before first administration of anti-VEGF treatment) and month 1, and 2; macular morphologic changes and outer retina characteristics (SD-OCT findings) associated with CNV activity were evaluated. Sensitivity and specificity were calculated for SD-OCT findings using fluorescein angiography (FA) as standard reference. Results: Mean central retinal thickness (CRT) showed no significant reduction from baseline (284±98 μm) to month 1 (257±74 μm) and month 2 (263±72 μm). A hyper-reflective lesion with fuzzy borders (fuzzy area), and 'absent or altered' IS/OS junction were the only SD-OCT findings associated with CNV activity (P

Original languageEnglish
Pages (from-to)976-982
Number of pages7
JournalEye (London, England)
Issue number7
Publication statusPublished - Jul 2012


  • anti-VEGF
  • choroidal neovascularization
  • pathologic myopia
  • spectral-domain OCT

ASJC Scopus subject areas

  • Ophthalmology


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