Abstract
Purpose: To evaluate changes in macular morphology due to myopic choroidal neovascularization (CNV), using spectral-domain optical coherence tomography (SD-OCT). Methods: In all, 22 eyes with recent-onset untreated CNV underwent 1 intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF), followed by a pro-re-nata regimen. SD-OCT was performed at baseline (before first administration of anti-VEGF treatment) and month 1, and 2; macular morphologic changes and outer retina characteristics (SD-OCT findings) associated with CNV activity were evaluated. Sensitivity and specificity were calculated for SD-OCT findings using fluorescein angiography (FA) as standard reference. Results: Mean central retinal thickness (CRT) showed no significant reduction from baseline (284±98 μm) to month 1 (257±74 μm) and month 2 (263±72 μm). A hyper-reflective lesion with fuzzy borders (fuzzy area), and 'absent or altered' IS/OS junction were the only SD-OCT findings associated with CNV activity (P
Original language | English |
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Pages (from-to) | 976-982 |
Number of pages | 7 |
Journal | Eye (London, England) |
Volume | 26 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2012 |
Keywords
- anti-VEGF
- choroidal neovascularization
- pathologic myopia
- spectral-domain OCT
ASJC Scopus subject areas
- Ophthalmology