Spectral-domain OCT in anti-VEGF treatment of myopic choroidal neovascularization

U. Introini; G. Casalino; G. Querques; A. T. Gimeno; F. Scotti; F. Bandello

doi:10.1038/eye.2012.75

Spectral-domain OCT in anti-VEGF treatment of myopic choroidal neovascularization

U. Introini, G. Casalino, G. Querques, A. T. Gimeno, F. Scotti, F. Bandello

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To evaluate changes in macular morphology due to myopic choroidal neovascularization (CNV), using spectral-domain optical coherence tomography (SD-OCT). Methods: In all, 22 eyes with recent-onset untreated CNV underwent 1 intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF), followed by a pro-re-nata regimen. SD-OCT was performed at baseline (before first administration of anti-VEGF treatment) and month 1, and 2; macular morphologic changes and outer retina characteristics (SD-OCT findings) associated with CNV activity were evaluated. Sensitivity and specificity were calculated for SD-OCT findings using fluorescein angiography (FA) as standard reference. Results: Mean central retinal thickness (CRT) showed no significant reduction from baseline (284±98 μm) to month 1 (257±74 μm) and month 2 (263±72 μm). A hyper-reflective lesion with fuzzy borders (fuzzy area), and 'absent or altered' IS/OS junction were the only SD-OCT findings associated with CNV activity (P

Original language	English
Pages (from-to)	976-982
Number of pages	7
Journal	Eye (London, England)
Volume	26
Issue number	7
DOIs	https://doi.org/10.1038/eye.2012.75
Publication status	Published - Jul 2012

Keywords

anti-VEGF
choroidal neovascularization
pathologic myopia
spectral-domain OCT

ASJC Scopus subject areas

Ophthalmology

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10.1038/eye.2012.75

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title = "Spectral-domain OCT in anti-VEGF treatment of myopic choroidal neovascularization",

abstract = "Purpose: To evaluate changes in macular morphology due to myopic choroidal neovascularization (CNV), using spectral-domain optical coherence tomography (SD-OCT). Methods: In all, 22 eyes with recent-onset untreated CNV underwent 1 intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF), followed by a pro-re-nata regimen. SD-OCT was performed at baseline (before first administration of anti-VEGF treatment) and month 1, and 2; macular morphologic changes and outer retina characteristics (SD-OCT findings) associated with CNV activity were evaluated. Sensitivity and specificity were calculated for SD-OCT findings using fluorescein angiography (FA) as standard reference. Results: Mean central retinal thickness (CRT) showed no significant reduction from baseline (284±98 μm) to month 1 (257±74 μm) and month 2 (263±72 μm). A hyper-reflective lesion with fuzzy borders (fuzzy area), and 'absent or altered' IS/OS junction were the only SD-OCT findings associated with CNV activity (P",

keywords = "anti-VEGF, choroidal neovascularization, pathologic myopia, spectral-domain OCT",

author = "U. Introini and G. Casalino and G. Querques and Gimeno, {A. T.} and F. Scotti and F. Bandello",

year = "2012",

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AU - Introini, U.

AU - Casalino, G.

AU - Querques, G.

AU - Gimeno, A. T.

AU - Scotti, F.

AU - Bandello, F.

PY - 2012/7

Y1 - 2012/7

N2 - Purpose: To evaluate changes in macular morphology due to myopic choroidal neovascularization (CNV), using spectral-domain optical coherence tomography (SD-OCT). Methods: In all, 22 eyes with recent-onset untreated CNV underwent 1 intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF), followed by a pro-re-nata regimen. SD-OCT was performed at baseline (before first administration of anti-VEGF treatment) and month 1, and 2; macular morphologic changes and outer retina characteristics (SD-OCT findings) associated with CNV activity were evaluated. Sensitivity and specificity were calculated for SD-OCT findings using fluorescein angiography (FA) as standard reference. Results: Mean central retinal thickness (CRT) showed no significant reduction from baseline (284±98 μm) to month 1 (257±74 μm) and month 2 (263±72 μm). A hyper-reflective lesion with fuzzy borders (fuzzy area), and 'absent or altered' IS/OS junction were the only SD-OCT findings associated with CNV activity (P

AB - Purpose: To evaluate changes in macular morphology due to myopic choroidal neovascularization (CNV), using spectral-domain optical coherence tomography (SD-OCT). Methods: In all, 22 eyes with recent-onset untreated CNV underwent 1 intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF), followed by a pro-re-nata regimen. SD-OCT was performed at baseline (before first administration of anti-VEGF treatment) and month 1, and 2; macular morphologic changes and outer retina characteristics (SD-OCT findings) associated with CNV activity were evaluated. Sensitivity and specificity were calculated for SD-OCT findings using fluorescein angiography (FA) as standard reference. Results: Mean central retinal thickness (CRT) showed no significant reduction from baseline (284±98 μm) to month 1 (257±74 μm) and month 2 (263±72 μm). A hyper-reflective lesion with fuzzy borders (fuzzy area), and 'absent or altered' IS/OS junction were the only SD-OCT findings associated with CNV activity (P

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KW - choroidal neovascularization

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Spectral-domain OCT in anti-VEGF treatment of myopic choroidal neovascularization

Abstract

Keywords

ASJC Scopus subject areas

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