Spectral domain optical coherence tomography findings in patients with retinitis pigmentosa

Giacinto Triolo, Luisa Pierro, Maurizio Battaglia Parodi, Umberto De Benedetto, Marco Gagliardi, Maria Pia Manitto, Francesco Bandello

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: To report the morphological macular findings detected by spectral domain optical coherence tomography (SD-OCT) and to determine their prevalence in patients with retinitis pigmentosa (RP). Methods: SD-OCT scans of 176 eyes from 90 patients affected by RP were reviewed. A careful evaluation was carried out on photoreceptor inner/outer segment (IS/OS) junction, external limiting membrane (ELM), inner limiting membrane thickening (ILMT), epiretinal membranes (ERMs), retinal micropseudocysts (MPCs), cystoid macular edema (CME), macular holes (MHs) and choroidal neovascularization (CNV). Results: The photoreceptor IS/OS junction was absent in the foveal region of 24 eyes (13.6%) and disrupted in 84 eyes (47.7%). The ELM was absent in 24 eyes (13.6%), whereas the ILMT was found in 118 eyes (67%). The presence of an ERM was detected in 48 eyes (27.3%). Some sort of vitreomacular alteration (ILMT and/or ERM) was identifiable in a total of 94.3% of eyes with RP. The presence of MPCs was detected in 32 eyes (18.2%). An evident CME was found in 22 eyes (12.5%). We also found MHs in 8 eyes (4.5%) and CNV in 3 eyes (1.7%). Conclusions: Our data indicate that RP is associated with alterations of many retinal layers. In particular, the vitreoretinal interface is affected in 94% of patients, and MPC can be identified in 18% of eyes. SD-OCT may contribute to the understanding of the pathophysiological mechanism involved in RP.

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalOphthalmic Research
Volume50
Issue number3
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Retinitis Pigmentosa
Optical Coherence Tomography
Epiretinal Membrane
Membranes
Choroidal Neovascularization
Retinal Perforations
Macular Edema

Keywords

  • Choroidal neovascularization
  • Cystoid macular edema
  • Epiretinal membranes
  • External limiting membrane
  • Inner limiting membrane thickening
  • Macular holes
  • Photoreceptor junction
  • Retinal micropseudocysts
  • Retinitis pigmentosa

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Spectral domain optical coherence tomography findings in patients with retinitis pigmentosa. / Triolo, Giacinto; Pierro, Luisa; Parodi, Maurizio Battaglia; De Benedetto, Umberto; Gagliardi, Marco; Manitto, Maria Pia; Bandello, Francesco.

In: Ophthalmic Research, Vol. 50, No. 3, 09.2013, p. 160-164.

Research output: Contribution to journalArticle

Triolo, Giacinto ; Pierro, Luisa ; Parodi, Maurizio Battaglia ; De Benedetto, Umberto ; Gagliardi, Marco ; Manitto, Maria Pia ; Bandello, Francesco. / Spectral domain optical coherence tomography findings in patients with retinitis pigmentosa. In: Ophthalmic Research. 2013 ; Vol. 50, No. 3. pp. 160-164.
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abstract = "Background: To report the morphological macular findings detected by spectral domain optical coherence tomography (SD-OCT) and to determine their prevalence in patients with retinitis pigmentosa (RP). Methods: SD-OCT scans of 176 eyes from 90 patients affected by RP were reviewed. A careful evaluation was carried out on photoreceptor inner/outer segment (IS/OS) junction, external limiting membrane (ELM), inner limiting membrane thickening (ILMT), epiretinal membranes (ERMs), retinal micropseudocysts (MPCs), cystoid macular edema (CME), macular holes (MHs) and choroidal neovascularization (CNV). Results: The photoreceptor IS/OS junction was absent in the foveal region of 24 eyes (13.6{\%}) and disrupted in 84 eyes (47.7{\%}). The ELM was absent in 24 eyes (13.6{\%}), whereas the ILMT was found in 118 eyes (67{\%}). The presence of an ERM was detected in 48 eyes (27.3{\%}). Some sort of vitreomacular alteration (ILMT and/or ERM) was identifiable in a total of 94.3{\%} of eyes with RP. The presence of MPCs was detected in 32 eyes (18.2{\%}). An evident CME was found in 22 eyes (12.5{\%}). We also found MHs in 8 eyes (4.5{\%}) and CNV in 3 eyes (1.7{\%}). Conclusions: Our data indicate that RP is associated with alterations of many retinal layers. In particular, the vitreoretinal interface is affected in 94{\%} of patients, and MPC can be identified in 18{\%} of eyes. SD-OCT may contribute to the understanding of the pathophysiological mechanism involved in RP.",
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AU - Triolo, Giacinto

AU - Pierro, Luisa

AU - Parodi, Maurizio Battaglia

AU - De Benedetto, Umberto

AU - Gagliardi, Marco

AU - Manitto, Maria Pia

AU - Bandello, Francesco

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AB - Background: To report the morphological macular findings detected by spectral domain optical coherence tomography (SD-OCT) and to determine their prevalence in patients with retinitis pigmentosa (RP). Methods: SD-OCT scans of 176 eyes from 90 patients affected by RP were reviewed. A careful evaluation was carried out on photoreceptor inner/outer segment (IS/OS) junction, external limiting membrane (ELM), inner limiting membrane thickening (ILMT), epiretinal membranes (ERMs), retinal micropseudocysts (MPCs), cystoid macular edema (CME), macular holes (MHs) and choroidal neovascularization (CNV). Results: The photoreceptor IS/OS junction was absent in the foveal region of 24 eyes (13.6%) and disrupted in 84 eyes (47.7%). The ELM was absent in 24 eyes (13.6%), whereas the ILMT was found in 118 eyes (67%). The presence of an ERM was detected in 48 eyes (27.3%). Some sort of vitreomacular alteration (ILMT and/or ERM) was identifiable in a total of 94.3% of eyes with RP. The presence of MPCs was detected in 32 eyes (18.2%). An evident CME was found in 22 eyes (12.5%). We also found MHs in 8 eyes (4.5%) and CNV in 3 eyes (1.7%). Conclusions: Our data indicate that RP is associated with alterations of many retinal layers. In particular, the vitreoretinal interface is affected in 94% of patients, and MPC can be identified in 18% of eyes. SD-OCT may contribute to the understanding of the pathophysiological mechanism involved in RP.

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KW - Retinal micropseudocysts

KW - Retinitis pigmentosa

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