Abstract
Background: To report the morphological macular findings detected by spectral domain optical coherence tomography (SD-OCT) and to determine their prevalence in patients with retinitis pigmentosa (RP). Methods: SD-OCT scans of 176 eyes from 90 patients affected by RP were reviewed. A careful evaluation was carried out on photoreceptor inner/outer segment (IS/OS) junction, external limiting membrane (ELM), inner limiting membrane thickening (ILMT), epiretinal membranes (ERMs), retinal micropseudocysts (MPCs), cystoid macular edema (CME), macular holes (MHs) and choroidal neovascularization (CNV). Results: The photoreceptor IS/OS junction was absent in the foveal region of 24 eyes (13.6%) and disrupted in 84 eyes (47.7%). The ELM was absent in 24 eyes (13.6%), whereas the ILMT was found in 118 eyes (67%). The presence of an ERM was detected in 48 eyes (27.3%). Some sort of vitreomacular alteration (ILMT and/or ERM) was identifiable in a total of 94.3% of eyes with RP. The presence of MPCs was detected in 32 eyes (18.2%). An evident CME was found in 22 eyes (12.5%). We also found MHs in 8 eyes (4.5%) and CNV in 3 eyes (1.7%). Conclusions: Our data indicate that RP is associated with alterations of many retinal layers. In particular, the vitreoretinal interface is affected in 94% of patients, and MPC can be identified in 18% of eyes. SD-OCT may contribute to the understanding of the pathophysiological mechanism involved in RP.
| Original language | English |
|---|---|
| Pages (from-to) | 160-164 |
| Number of pages | 5 |
| Journal | Ophthalmic Research |
| Volume | 50 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2013 |
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Keywords
- Choroidal neovascularization
- Cystoid macular edema
- Epiretinal membranes
- External limiting membrane
- Inner limiting membrane thickening
- Macular holes
- Photoreceptor junction
- Retinal micropseudocysts
- Retinitis pigmentosa
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
- Medicine(all)
Cite this
Spectral domain optical coherence tomography findings in patients with retinitis pigmentosa. / Triolo, Giacinto; Pierro, Luisa; Parodi, Maurizio Battaglia; De Benedetto, Umberto; Gagliardi, Marco; Manitto, Maria Pia; Bandello, Francesco.
In: Ophthalmic Research, Vol. 50, No. 3, 09.2013, p. 160-164.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spectral domain optical coherence tomography findings in patients with retinitis pigmentosa
AU - Triolo, Giacinto
AU - Pierro, Luisa
AU - Parodi, Maurizio Battaglia
AU - De Benedetto, Umberto
AU - Gagliardi, Marco
AU - Manitto, Maria Pia
AU - Bandello, Francesco
PY - 2013/9
Y1 - 2013/9
N2 - Background: To report the morphological macular findings detected by spectral domain optical coherence tomography (SD-OCT) and to determine their prevalence in patients with retinitis pigmentosa (RP). Methods: SD-OCT scans of 176 eyes from 90 patients affected by RP were reviewed. A careful evaluation was carried out on photoreceptor inner/outer segment (IS/OS) junction, external limiting membrane (ELM), inner limiting membrane thickening (ILMT), epiretinal membranes (ERMs), retinal micropseudocysts (MPCs), cystoid macular edema (CME), macular holes (MHs) and choroidal neovascularization (CNV). Results: The photoreceptor IS/OS junction was absent in the foveal region of 24 eyes (13.6%) and disrupted in 84 eyes (47.7%). The ELM was absent in 24 eyes (13.6%), whereas the ILMT was found in 118 eyes (67%). The presence of an ERM was detected in 48 eyes (27.3%). Some sort of vitreomacular alteration (ILMT and/or ERM) was identifiable in a total of 94.3% of eyes with RP. The presence of MPCs was detected in 32 eyes (18.2%). An evident CME was found in 22 eyes (12.5%). We also found MHs in 8 eyes (4.5%) and CNV in 3 eyes (1.7%). Conclusions: Our data indicate that RP is associated with alterations of many retinal layers. In particular, the vitreoretinal interface is affected in 94% of patients, and MPC can be identified in 18% of eyes. SD-OCT may contribute to the understanding of the pathophysiological mechanism involved in RP.
AB - Background: To report the morphological macular findings detected by spectral domain optical coherence tomography (SD-OCT) and to determine their prevalence in patients with retinitis pigmentosa (RP). Methods: SD-OCT scans of 176 eyes from 90 patients affected by RP were reviewed. A careful evaluation was carried out on photoreceptor inner/outer segment (IS/OS) junction, external limiting membrane (ELM), inner limiting membrane thickening (ILMT), epiretinal membranes (ERMs), retinal micropseudocysts (MPCs), cystoid macular edema (CME), macular holes (MHs) and choroidal neovascularization (CNV). Results: The photoreceptor IS/OS junction was absent in the foveal region of 24 eyes (13.6%) and disrupted in 84 eyes (47.7%). The ELM was absent in 24 eyes (13.6%), whereas the ILMT was found in 118 eyes (67%). The presence of an ERM was detected in 48 eyes (27.3%). Some sort of vitreomacular alteration (ILMT and/or ERM) was identifiable in a total of 94.3% of eyes with RP. The presence of MPCs was detected in 32 eyes (18.2%). An evident CME was found in 22 eyes (12.5%). We also found MHs in 8 eyes (4.5%) and CNV in 3 eyes (1.7%). Conclusions: Our data indicate that RP is associated with alterations of many retinal layers. In particular, the vitreoretinal interface is affected in 94% of patients, and MPC can be identified in 18% of eyes. SD-OCT may contribute to the understanding of the pathophysiological mechanism involved in RP.
KW - Choroidal neovascularization
KW - Cystoid macular edema
KW - Epiretinal membranes
KW - External limiting membrane
KW - Inner limiting membrane thickening
KW - Macular holes
KW - Photoreceptor junction
KW - Retinal micropseudocysts
KW - Retinitis pigmentosa
UR - http://www.scopus.com/inward/record.url?scp=84884779870&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884779870&partnerID=8YFLogxK
U2 - 10.1159/000351681
DO - 10.1159/000351681
M3 - Article
VL - 50
SP - 160
EP - 164
JO - Ophthalmic Research
JF - Ophthalmic Research
SN - 0030-3747
IS - 3
ER -