Spectrally weighted Granger-causal modeling: Motivation and applications to data from animal models and epileptic patients

Gijs Plomp, Laura Astolfi, Ana Coito, Christoph M. Michel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper we motivate and describe spectral weighting in methods based on the Granger-causal modeling framework. We show how these methods were validated in recordings from an animal model (rats) with relatively well-understood dynamic connectivity, and provide a comparison of their performances in terms of physiological interpretability and time resolution. Having shown that spectrally weighted Partial Directed Coherence (wPDC) shows good performances in real animal data, we provide an example of the application of this method to EEG data recorded from patients with left or right temporal lobe epilepsy. The result showed that wPDC correctly identified the major drivers of interictal epileptic spiking activity, in line with invasive validation and surgical outcome, and furthermore that right temporal lobe epilepsy is characterized by more inter-hemispheric influence than left temporal lobe epilepsy.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5392-5395
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
Publication statusPublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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    Plomp, G., Astolfi, L., Coito, A., & Michel, C. M. (2015). Spectrally weighted Granger-causal modeling: Motivation and applications to data from animal models and epileptic patients. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 5392-5395). [7319610] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319610