Spectroscopic, diffusion and perfusion magnetic resonance imaging at 3.0 Tesla in the delineation of glioblastomas: Preliminary results

Alfonso Di Costanzo, F. Trojsi, G. M. Giannatempo, L. Vuolo, T. Popolizio, D. Catapano, S. Bonavita, V. A. D'Angelo, G. Tedeschi, T. Scarabino

Research output: Contribution to journalArticlepeer-review


Recent advances in magnetic resonance imaging (MRI) have allowed the evaluation of metabolic, diffusion and hemodynamic features of malignant gliomas. The aim of this study was to evaluate whether such information provided useful, complementary information to conventional MRI for improving the evaluation of glioblastoma extent. Ten patients with glioblastoma multiforme underwent conventional MRI, proton MR spectroscopic imaging (1H-MRSI), perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI). Metabolite signals, including normalized choline, N-acetylaspartate, creatine and lactate/lipids, were obtained by 1H-MRSI; apparent diffusion coefficient (ADC) by DWI; and relative cerebral blood volume (rCBV) by PWI. In edematous-appearing areas, 3 multiparametric patterns were identified: infiltrating tumor, with abnormal metabolite ratios, lower ADC and higher rCBV; pure edema, with normal metabolite ratios, higher ADC and lower rCBV; and tumor-infiltrated edema, with abnormal metabolite ratios and intermediate ADC and rCBV. In normal-appearing areas, 2 multiparametric patterns were identified: tumor-infiltrated tissue, with abnormal metabolite ratios and higher rCBV; and normal tissue, with normal MR parameters. The combination of 1H-MRSI, DWI and PWI features contributed to delineation of glioblastomas, offering information not available with conventional MRI. This approach may enhance the assessment of brain gliomas, providing useful information for guiding stereotactic biopsies, surgical resection and radiation treatment.

Original languageEnglish
Pages (from-to)383-390
Number of pages8
JournalJournal of Experimental and Clinical Cancer Research
Issue number3
Publication statusPublished - Sep 2006


  • Apparent diffusion coefficient
  • Cerebral blood volume
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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