Spectroscopic study of mandibular bone in ovariectomised rats

M. Mattioli-Belmonte, G. Albergo, M. Fini, R. Di Giorgio, M. Montella, N. Nicoli-Aldini, L. De Florio, G. Gualandi, G. Biagini

Research output: Contribution to journalArticle

Abstract

Background. The extent of the mandibular bone loss occurring in conditions which like ovariectomy induce an osteopaenia analogous to that resulting from postmenopausal skeletal osteoporosis is unclear. In oral-cavity osteopaenia is influenced by several specific factors among which mechanical stress, radicular-dental filling, and interaction with inflammatory/regenerative processes of the periodontium. In the present study, the mandibles of ovariectomised rats were subjected to spectroscopic analysis to assess whether and to what extent the structure and the Calcium (Ca) and Phosphorus (P) content of the mandible can be indicative of a state of altered quality of the bone texture. Methods. Female Sprague-Dawley rats were used. Bilateral ovariectomies were performed on 21 rats and sham surgery was performed on 8 rats. The right mandibles were collected, observed by back-scattered electron imaging and then subjected to X-ray microanalysis. Results. Nine measurements were performed on each sample and their means were compared. This analysis did not evidence significant differences in the content of Ca and P nor in the Ca/P ratio. No significant differences in the samples subjected to SEM were observed. Conclusions. The results suggest the influence or interference of other factors like periodontal pathological processes, abnormal masticatory stress and state of the existing teeth in determining mandibular osteoporosis also at experimental level. The study of parameters such as the state of bone trabeculae, mineral density and existing periodontal conditions is therefore indispensable to evaluate bone quantity and must always be taken into consideration in any dental treatment of the oral cavity.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalItalian Journal of Mineral and Electrolyte Metabolism
Volume15
Issue number1-4
Publication statusPublished - 2001

Fingerprint

Mandible
Rats
Tooth
Bone
Ovariectomy
Calcium
Bone and Bones
Mouth
Electron Probe Microanalysis
Periodontium
Mechanical Stress
Postmenopausal Osteoporosis
Pathologic Processes
Bone Density
Phosphorus
Dental prostheses
Osteoporosis
Spectroscopic analysis
Sprague Dawley Rats
Electrons

Keywords

  • Experimental study
  • Mandibular bone
  • Microanalysis
  • Osteoporosis

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Mattioli-Belmonte, M., Albergo, G., Fini, M., Di Giorgio, R., Montella, M., Nicoli-Aldini, N., ... Biagini, G. (2001). Spectroscopic study of mandibular bone in ovariectomised rats. Italian Journal of Mineral and Electrolyte Metabolism, 15(1-4), 9-13.

Spectroscopic study of mandibular bone in ovariectomised rats. / Mattioli-Belmonte, M.; Albergo, G.; Fini, M.; Di Giorgio, R.; Montella, M.; Nicoli-Aldini, N.; De Florio, L.; Gualandi, G.; Biagini, G.

In: Italian Journal of Mineral and Electrolyte Metabolism, Vol. 15, No. 1-4, 2001, p. 9-13.

Research output: Contribution to journalArticle

Mattioli-Belmonte, M, Albergo, G, Fini, M, Di Giorgio, R, Montella, M, Nicoli-Aldini, N, De Florio, L, Gualandi, G & Biagini, G 2001, 'Spectroscopic study of mandibular bone in ovariectomised rats', Italian Journal of Mineral and Electrolyte Metabolism, vol. 15, no. 1-4, pp. 9-13.
Mattioli-Belmonte, M. ; Albergo, G. ; Fini, M. ; Di Giorgio, R. ; Montella, M. ; Nicoli-Aldini, N. ; De Florio, L. ; Gualandi, G. ; Biagini, G. / Spectroscopic study of mandibular bone in ovariectomised rats. In: Italian Journal of Mineral and Electrolyte Metabolism. 2001 ; Vol. 15, No. 1-4. pp. 9-13.
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AU - Gualandi, G.

AU - Biagini, G.

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AB - Background. The extent of the mandibular bone loss occurring in conditions which like ovariectomy induce an osteopaenia analogous to that resulting from postmenopausal skeletal osteoporosis is unclear. In oral-cavity osteopaenia is influenced by several specific factors among which mechanical stress, radicular-dental filling, and interaction with inflammatory/regenerative processes of the periodontium. In the present study, the mandibles of ovariectomised rats were subjected to spectroscopic analysis to assess whether and to what extent the structure and the Calcium (Ca) and Phosphorus (P) content of the mandible can be indicative of a state of altered quality of the bone texture. Methods. Female Sprague-Dawley rats were used. Bilateral ovariectomies were performed on 21 rats and sham surgery was performed on 8 rats. The right mandibles were collected, observed by back-scattered electron imaging and then subjected to X-ray microanalysis. Results. Nine measurements were performed on each sample and their means were compared. This analysis did not evidence significant differences in the content of Ca and P nor in the Ca/P ratio. No significant differences in the samples subjected to SEM were observed. Conclusions. The results suggest the influence or interference of other factors like periodontal pathological processes, abnormal masticatory stress and state of the existing teeth in determining mandibular osteoporosis also at experimental level. The study of parameters such as the state of bone trabeculae, mineral density and existing periodontal conditions is therefore indispensable to evaluate bone quantity and must always be taken into consideration in any dental treatment of the oral cavity.

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