Spectrum of cognitive disorders in idiopathic normal pressure hydrocephalus

Marta Picascia, Brigida Minafra, Roberta Zangaglia, Luciana Gracardi, Nicolò Gabriele Pozzi, Elena Sinforiani, Claudio Pacchetti

Research output: Contribution to journalArticlepeer-review


Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome characterized by ventricular dilation accompanied by a progressive triad of a gait disturbance, “dementia” and incontinence. We retrospectively evaluated cognitive profile, and its relationship with disease variables, in 64 iNPH patients. The iNPH group performed significantly worse than the control group on all neuropsychological tests, except for verbal memory (within the normal range). The patients were subdivided into four groups: group 1 (42%: global cognitive impairment); group 2 (24%: frontosubcortical dysfunction); group 3 (17%: isolated deficit of a single cognitive domain); group 4 (17%: no cognitive impairment). Group 1 was older, with a significantly longer disease duration and more severe motor disease, while groups 3 and 4 were younger and presented milder motor impairment and a shorter disease duration. These data suggest parallel progression of cognitive and motor impairment in iNPH; early shunt surgery might prevent the development, in older age, of dementia in these patients.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalFunctional Neurology
Issue number3
Publication statusPublished - Jul 1 2016


  • Cognitive disorders
  • Disease duration
  • Gait disturbances
  • Idiopathic normal pressure hydrocephalus
  • Parkinsonism

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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