Sperm Protein 17 Is Expressed in Human Somatic Ciliated Epithelia

Fabio Grizzi, Maurizio Chiriva-Internati, Barbara Franceschini, Klaus Bumm, Piergiuseppe Colombo, Michele Ciccarelli, Elena Donetti, Nicoletta Gagliano, Paul L. Hermonat, Robert K. Bright, Magda Gioia, Nicola Dioguardi, W. Martin Kast

Research output: Contribution to journalArticlepeer-review

Abstract

It was once believed that sperm protein 17 (Sp17) was expressed exclusively in the testis and that its sole function was to bind to the oocyte during fertilization. However, immunohistochemistry of the human respiratory airways and reproductive systems show that it is abundant in ciliated cells but not in human cells with stereocilia and microvilli. The high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP)-binding motif within this region, suggest that Sp17 plays a regulatory role in a PKA-independent AKAP complex in both male germinal and ciliated somatic cells.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalJournal of Histochemistry and Cytochemistry
Volume52
Issue number4
Publication statusPublished - Apr 2004

Keywords

  • Cilia
  • Immunohistochemistry
  • Microvilli
  • Reproductive system
  • Respiratory system
  • Sperm protein 17

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Fingerprint

Dive into the research topics of 'Sperm Protein 17 Is Expressed in Human Somatic Ciliated Epithelia'. Together they form a unique fingerprint.

Cite this