TY - JOUR
T1 - Spermatic Cord Sarcoma: A 20-Year Single-Institution Experience
AU - Iafrate, Massimo
AU - Motterle, Giovanni
AU - Zaborra, Carlotta
AU - Leone, Niccolò
AU - Prayer-Galetti, Tommaso
AU - Zattoni, Filiberto
AU - Guttilla, Andrea
AU - Cappellesso, Rocco
AU - Dei Tos, Angelo Paolo
AU - Rossi, Carlo Riccardo
AU - Del Fiore, Paolo
AU - Rastrelli, Marco
AU - Mocellin, Simone
N1 - Publisher Copyright:
© Copyright © 2020 Iafrate, Motterle, Zaborra, Leone, Prayer-Galetti, Zattoni, Guttilla, Cappellesso, Dei Tos, Rossi, Del Fiore, Rastrelli and Mocellin.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/17
Y1 - 2020/11/17
N2 - Introduction: Spermatic cord sarcomas represent a rare genitourinary malignancy with a challenging diagnostic and therapeutic pathway. Different histotypes have been described and prognostic factors remain poorly defined due to the paucity of data presented in literature. Methods: Retrospective chart review of 22 adult patients treated for spermatic cord sarcoma in a single institution in the last 20 years was performed. Clinicopathological characteristics of the tumors were collected with primary and subsequent treatment. Survival analysis was performed in order to identify prognostic factors of disease-specific survival. Results: The median age at diagnosis was 68 years (58–78), the most common histotype was liposarcoma (14/22), and most patients (63.6%) were found to have positive surgical margins after surgery. The 5-year cancer specific survival was 91.3%. Grading (p = 0.480), histotype (p = 0.327), and type of intervention (p = 0.732) were not associated with survival. All patients dead of disease had positive surgical margins (p = 0.172). Conclusion: We report a good prognosis at 5 years. Wide radical resection remains the first and probably the most important step; thus, according also to literature, negative surgical margins should be aimed.
AB - Introduction: Spermatic cord sarcomas represent a rare genitourinary malignancy with a challenging diagnostic and therapeutic pathway. Different histotypes have been described and prognostic factors remain poorly defined due to the paucity of data presented in literature. Methods: Retrospective chart review of 22 adult patients treated for spermatic cord sarcoma in a single institution in the last 20 years was performed. Clinicopathological characteristics of the tumors were collected with primary and subsequent treatment. Survival analysis was performed in order to identify prognostic factors of disease-specific survival. Results: The median age at diagnosis was 68 years (58–78), the most common histotype was liposarcoma (14/22), and most patients (63.6%) were found to have positive surgical margins after surgery. The 5-year cancer specific survival was 91.3%. Grading (p = 0.480), histotype (p = 0.327), and type of intervention (p = 0.732) were not associated with survival. All patients dead of disease had positive surgical margins (p = 0.172). Conclusion: We report a good prognosis at 5 years. Wide radical resection remains the first and probably the most important step; thus, according also to literature, negative surgical margins should be aimed.
KW - paratesticular sarcoma
KW - soft tissue sarcoma
KW - spermatic cord
KW - spermatic cord sarcoma
KW - treatment
KW - urologic sarcoma
UR - http://www.scopus.com/inward/record.url?scp=85097072242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097072242&partnerID=8YFLogxK
U2 - 10.3389/fsurg.2020.566408
DO - 10.3389/fsurg.2020.566408
M3 - Article
AN - SCOPUS:85097072242
VL - 7
JO - Frontiers in Surgery
JF - Frontiers in Surgery
SN - 2296-875X
M1 - 566408
ER -