Spheroplasts, poorly known but clinically relevant particles of urinary sediment

Rosanna Falbo, Giovanni Battista Fogazzi, Maria Roberta Sala, Giuseppe Garigali, Adela Sulejmani, Paolo Brambilla, Valerio Leoni

Research output: Contribution to journalArticlepeer-review


Background: In two patients under treatment with various antibiotics, spheroplasts were detected with an automated urine sediment analyzer. Methods: Urinalysis was performed by an AutionMAX AX 4030-sediMAX platform. Results: Spheroplasts can be easily misclassified as yeasts or erythrocytes, but when automated urine sediment analyzers are used by well-trained, and experienced operators they can be correctly identified and classified. Conclusion: Appropriate training of urine laboratory professionals in spheroplast detection and association with UTI, together with timely communication with the microbiologist and caring clinician, will provide prompt targeted treatment.

Original languageEnglish
Pages (from-to)13-15
Number of pages3
JournalClinica Chimica Acta
Publication statusPublished - Apr 2021


  • SediMAX
  • Spheroplasts
  • ß-lactam antibiotics
  • Urinalysis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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