Spheroplasts, poorly known but clinically relevant particles of urinary sediment

Rosanna Falbo; Giovanni Battista Fogazzi; Maria Roberta Sala; Giuseppe Garigali; Adela Sulejmani; Paolo Brambilla; Valerio Leoni

doi:10.1016/j.cca.2020.12.026

Spheroplasts, poorly known but clinically relevant particles of urinary sediment

Rosanna Falbo, Giovanni Battista Fogazzi, Maria Roberta Sala, Giuseppe Garigali, Adela Sulejmani, Paolo Brambilla, Valerio Leoni

Research output: Contribution to journal › Article › peer-review

Abstract

Background: In two patients under treatment with various antibiotics, spheroplasts were detected with an automated urine sediment analyzer. Methods: Urinalysis was performed by an AutionMAX AX 4030-sediMAX platform. Results: Spheroplasts can be easily misclassified as yeasts or erythrocytes, but when automated urine sediment analyzers are used by well-trained, and experienced operators they can be correctly identified and classified. Conclusion: Appropriate training of urine laboratory professionals in spheroplast detection and association with UTI, together with timely communication with the microbiologist and caring clinician, will provide prompt targeted treatment.

Original language	English
Pages (from-to)	13-15
Number of pages	3
Journal	Clinica Chimica Acta
Volume	515
DOIs	https://doi.org/10.1016/j.cca.2020.12.026
Publication status	Published - Apr 2021

Keywords

SediMAX
Spheroplasts
ß-lactam antibiotics
Urinalysis

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

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Cite this

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title = "Spheroplasts, poorly known but clinically relevant particles of urinary sediment",

abstract = "Background: In two patients under treatment with various antibiotics, spheroplasts were detected with an automated urine sediment analyzer. Methods: Urinalysis was performed by an AutionMAX AX 4030-sediMAX platform. Results: Spheroplasts can be easily misclassified as yeasts or erythrocytes, but when automated urine sediment analyzers are used by well-trained, and experienced operators they can be correctly identified and classified. Conclusion: Appropriate training of urine laboratory professionals in spheroplast detection and association with UTI, together with timely communication with the microbiologist and caring clinician, will provide prompt targeted treatment.",

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year = "2021",

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T1 - Spheroplasts, poorly known but clinically relevant particles of urinary sediment

AU - Falbo, Rosanna

AU - Fogazzi, Giovanni Battista

AU - Sala, Maria Roberta

AU - Garigali, Giuseppe

AU - Sulejmani, Adela

AU - Brambilla, Paolo

AU - Leoni, Valerio

PY - 2021/4

Y1 - 2021/4

N2 - Background: In two patients under treatment with various antibiotics, spheroplasts were detected with an automated urine sediment analyzer. Methods: Urinalysis was performed by an AutionMAX AX 4030-sediMAX platform. Results: Spheroplasts can be easily misclassified as yeasts or erythrocytes, but when automated urine sediment analyzers are used by well-trained, and experienced operators they can be correctly identified and classified. Conclusion: Appropriate training of urine laboratory professionals in spheroplast detection and association with UTI, together with timely communication with the microbiologist and caring clinician, will provide prompt targeted treatment.

AB - Background: In two patients under treatment with various antibiotics, spheroplasts were detected with an automated urine sediment analyzer. Methods: Urinalysis was performed by an AutionMAX AX 4030-sediMAX platform. Results: Spheroplasts can be easily misclassified as yeasts or erythrocytes, but when automated urine sediment analyzers are used by well-trained, and experienced operators they can be correctly identified and classified. Conclusion: Appropriate training of urine laboratory professionals in spheroplast detection and association with UTI, together with timely communication with the microbiologist and caring clinician, will provide prompt targeted treatment.

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KW - ß-lactam antibiotics

KW - Urinalysis

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