Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells

Paola Giussani, Anita Ferraretto, Claudia Gravaghi, Rosaria Bassi, Guido Tettamanti, Laura Riboni, Paola Viani

Research output: Contribution to journalArticlepeer-review

Abstract

S1P is involved in the regulation of multiple biological processes (cell survival, growth, migration and differentiation) both in neurons and glial cells. The study was aimed at investigating the possible effects of S1P on calcium signaling in cerebellar astrocytes and differentiated granule cells. In cerebellar astrocytes S1P is able to mediate calcium signaling mainly through Gi protein coupled receptors, whereas in differentiated neurons it failed to evoke any calcium signaling, despite acting both extracellularly and intracellularly. The data indicate strict cell specificity in S1P-evoked calcium response, which could be relevant to communication between neurons and glial cells in the cerebellum.

Original languageEnglish
Pages (from-to)27-37
Number of pages11
JournalNeurochemical Research
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Calcium signalling
  • Cerebellar astrocytes
  • Cerebellar granule cells
  • Sphingosine-1-phosphate
  • Videoimaging

ASJC Scopus subject areas

  • Biochemistry
  • Neuroscience(all)

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