Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells

Paola Giussani; Anita Ferraretto; Claudia Gravaghi; Rosaria Bassi; Guido Tettamanti; Laura Riboni; Paola Viani

doi:10.1007/s11064-006-9219-3

Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells

Paola Giussani, Anita Ferraretto, Claudia Gravaghi, Rosaria Bassi, Guido Tettamanti, Laura Riboni, Paola Viani

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

S1P is involved in the regulation of multiple biological processes (cell survival, growth, migration and differentiation) both in neurons and glial cells. The study was aimed at investigating the possible effects of S1P on calcium signaling in cerebellar astrocytes and differentiated granule cells. In cerebellar astrocytes S1P is able to mediate calcium signaling mainly through G_i protein coupled receptors, whereas in differentiated neurons it failed to evoke any calcium signaling, despite acting both extracellularly and intracellularly. The data indicate strict cell specificity in S1P-evoked calcium response, which could be relevant to communication between neurons and glial cells in the cerebellum.

Original language	English
Pages (from-to)	27-37
Number of pages	11
Journal	Neurochemical Research
Volume	32
Issue number	1
DOIs	https://doi.org/10.1007/s11064-006-9219-3
Publication status	Published - Jan 2007

Keywords

Calcium signalling
Cerebellar astrocytes
Cerebellar granule cells
Sphingosine-1-phosphate
Videoimaging

ASJC Scopus subject areas

Biochemistry
Neuroscience(all)

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abstract = "S1P is involved in the regulation of multiple biological processes (cell survival, growth, migration and differentiation) both in neurons and glial cells. The study was aimed at investigating the possible effects of S1P on calcium signaling in cerebellar astrocytes and differentiated granule cells. In cerebellar astrocytes S1P is able to mediate calcium signaling mainly through Gi protein coupled receptors, whereas in differentiated neurons it failed to evoke any calcium signaling, despite acting both extracellularly and intracellularly. The data indicate strict cell specificity in S1P-evoked calcium response, which could be relevant to communication between neurons and glial cells in the cerebellum.",

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AU - Giussani, Paola

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AU - Gravaghi, Claudia

AU - Bassi, Rosaria

AU - Tettamanti, Guido

AU - Riboni, Laura

AU - Viani, Paola

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Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells

Abstract

Keywords

ASJC Scopus subject areas

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