Sphingosine-1-phosphate receptor modulators and oligodendroglial cells: Beyond immunomodulation

Alessandra Roggeri, Melissa Schepers, Assia Tiane, Ben Rombaut, Lieve Van Veggel, Niels Hellings, Jos Prickaerts, Anna Pittaluga, Tim Vanmierlo

Research output: Contribution to journalReview articlepeer-review

Abstract

Multiple sclerosis (MS) is an autoimmune inflammatory disease characterized by demyelination, axonal loss, and synaptic impairment in the central nervous system (CNS). The available therapies aim to reduce the severity of the pathology during the early inflammatory stages, but they are not effective in the chronic stage of the disease. In this phase, failure in endogenous remyelination is associated with the impairment of oligodendrocytes progenitor cells (OPCs) to migrate and differentiate into mature myelinating oligodendrocytes. Therefore, stimulating differentiation of OPCs into myelinating oligodendrocytes has become one of the main goals of new therapeutic approaches for MS. Different disease-modifying therapies targeting sphingosine-1-phosphate receptors (S1PRs) have been approved or are being developed to treat MS. Besides their immunomodulatory effects, growing evidence suggests that targeting S1PRs modulates mechanisms beyond immunomodulation, such as remyelination. In this context, this review focuses on the current understanding of S1PR modulators and their direct effect on OPCs and oligodendrocytes.

Original languageEnglish
Article number7537
Pages (from-to)1-24
Number of pages24
JournalInternational Journal of Molecular Sciences
Volume21
Issue number20
DOIs
Publication statusPublished - Oct 2 2020

Keywords

  • Demyelination
  • Multiple sclerosis
  • Oligodendrocyte
  • OPC
  • Sphingosine-1-phosphate receptor modulators

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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