Spinal cord injury (SCI) is one of the most frustrating maladies faced in neurology and medicine. The vast majority of traumatic SCI patients are young, and most survivors of significant injury face the prospect of limited recovery and permanent disability. The incidence of new SCI is high, and in Italy it has been increasing dramatically recently. In the United States, the number is more than 12. 000 new cases per year of paraplegia or quadriplegia. The total number is more than 1 × 1000 living persons. A similar rate has also been reported for Italy. The need for effective interventions, both to limit the number of permanently impaired patients and to give real hope to the newly injured, has never been greater.
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