Spinal-cord MRI in multiple sclerosis

Geert Lycklama, Alan Thompson, Massimo Filippi, David Miller, Chris Polman, Franz Fazekas, Frederik Barkhof

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

The potential of MRI of the spinal cord as a diagnostic tool in MS has recently gained much interest. Dual echo spin echo MRI is most sensitive for the detection of spinal-cord abnormalities, which range from multiple focal lesions to confluent areas of high signal intensity. In some patients, commonly those with primary progressive disease, diffuse areas of slightly increased signal intensity are found. Disappointingly, the relation between MRI findings and clinical disability is weak. Studies relating MRI findings with histopathology have revealed substantial axonal loss in the spinal cords of patients with MS, whether focal lesions are present of not. Further, diffuse cord atrophy is found in advanced MS, which may reflect axonal loss. In the diagnostic setting, spinal-cord imaging is valuable. First, asymptomatic spinal-cord lesions are very rare in disorders other than MS. For example, in a patient with equivocal brain findings such as an elderly patient with vascular-ischaemic lesions, a normal spinal-cord examination can help rule out MS. Second, presence of asymptomatic spinal lesions may help confirm a diagnosis of MS when few or no brain lesions are present.

Original languageEnglish
Pages (from-to)555-562
Number of pages8
JournalThe Lancet Neurology
Volume2
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Multiple Sclerosis
Spinal Cord
Brain
Atrophy
Blood Vessels

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lycklama, G., Thompson, A., Filippi, M., Miller, D., Polman, C., Fazekas, F., & Barkhof, F. (2003). Spinal-cord MRI in multiple sclerosis. The Lancet Neurology, 2(9), 555-562. https://doi.org/10.1016/S1474-4422(03)00504-0

Spinal-cord MRI in multiple sclerosis. / Lycklama, Geert; Thompson, Alan; Filippi, Massimo; Miller, David; Polman, Chris; Fazekas, Franz; Barkhof, Frederik.

In: The Lancet Neurology, Vol. 2, No. 9, 01.09.2003, p. 555-562.

Research output: Contribution to journalArticle

Lycklama, G, Thompson, A, Filippi, M, Miller, D, Polman, C, Fazekas, F & Barkhof, F 2003, 'Spinal-cord MRI in multiple sclerosis', The Lancet Neurology, vol. 2, no. 9, pp. 555-562. https://doi.org/10.1016/S1474-4422(03)00504-0
Lycklama G, Thompson A, Filippi M, Miller D, Polman C, Fazekas F et al. Spinal-cord MRI in multiple sclerosis. The Lancet Neurology. 2003 Sep 1;2(9):555-562. https://doi.org/10.1016/S1474-4422(03)00504-0
Lycklama, Geert ; Thompson, Alan ; Filippi, Massimo ; Miller, David ; Polman, Chris ; Fazekas, Franz ; Barkhof, Frederik. / Spinal-cord MRI in multiple sclerosis. In: The Lancet Neurology. 2003 ; Vol. 2, No. 9. pp. 555-562.
@article{9a93e7c6a0ea4cc5afb8d020e7245114,
title = "Spinal-cord MRI in multiple sclerosis",
abstract = "The potential of MRI of the spinal cord as a diagnostic tool in MS has recently gained much interest. Dual echo spin echo MRI is most sensitive for the detection of spinal-cord abnormalities, which range from multiple focal lesions to confluent areas of high signal intensity. In some patients, commonly those with primary progressive disease, diffuse areas of slightly increased signal intensity are found. Disappointingly, the relation between MRI findings and clinical disability is weak. Studies relating MRI findings with histopathology have revealed substantial axonal loss in the spinal cords of patients with MS, whether focal lesions are present of not. Further, diffuse cord atrophy is found in advanced MS, which may reflect axonal loss. In the diagnostic setting, spinal-cord imaging is valuable. First, asymptomatic spinal-cord lesions are very rare in disorders other than MS. For example, in a patient with equivocal brain findings such as an elderly patient with vascular-ischaemic lesions, a normal spinal-cord examination can help rule out MS. Second, presence of asymptomatic spinal lesions may help confirm a diagnosis of MS when few or no brain lesions are present.",
author = "Geert Lycklama and Alan Thompson and Massimo Filippi and David Miller and Chris Polman and Franz Fazekas and Frederik Barkhof",
year = "2003",
month = "9",
day = "1",
doi = "10.1016/S1474-4422(03)00504-0",
language = "English",
volume = "2",
pages = "555--562",
journal = "The Lancet Neurology",
issn = "1474-4422",
publisher = "Lancet Publishing Group",
number = "9",

}

TY - JOUR

T1 - Spinal-cord MRI in multiple sclerosis

AU - Lycklama, Geert

AU - Thompson, Alan

AU - Filippi, Massimo

AU - Miller, David

AU - Polman, Chris

AU - Fazekas, Franz

AU - Barkhof, Frederik

PY - 2003/9/1

Y1 - 2003/9/1

N2 - The potential of MRI of the spinal cord as a diagnostic tool in MS has recently gained much interest. Dual echo spin echo MRI is most sensitive for the detection of spinal-cord abnormalities, which range from multiple focal lesions to confluent areas of high signal intensity. In some patients, commonly those with primary progressive disease, diffuse areas of slightly increased signal intensity are found. Disappointingly, the relation between MRI findings and clinical disability is weak. Studies relating MRI findings with histopathology have revealed substantial axonal loss in the spinal cords of patients with MS, whether focal lesions are present of not. Further, diffuse cord atrophy is found in advanced MS, which may reflect axonal loss. In the diagnostic setting, spinal-cord imaging is valuable. First, asymptomatic spinal-cord lesions are very rare in disorders other than MS. For example, in a patient with equivocal brain findings such as an elderly patient with vascular-ischaemic lesions, a normal spinal-cord examination can help rule out MS. Second, presence of asymptomatic spinal lesions may help confirm a diagnosis of MS when few or no brain lesions are present.

AB - The potential of MRI of the spinal cord as a diagnostic tool in MS has recently gained much interest. Dual echo spin echo MRI is most sensitive for the detection of spinal-cord abnormalities, which range from multiple focal lesions to confluent areas of high signal intensity. In some patients, commonly those with primary progressive disease, diffuse areas of slightly increased signal intensity are found. Disappointingly, the relation between MRI findings and clinical disability is weak. Studies relating MRI findings with histopathology have revealed substantial axonal loss in the spinal cords of patients with MS, whether focal lesions are present of not. Further, diffuse cord atrophy is found in advanced MS, which may reflect axonal loss. In the diagnostic setting, spinal-cord imaging is valuable. First, asymptomatic spinal-cord lesions are very rare in disorders other than MS. For example, in a patient with equivocal brain findings such as an elderly patient with vascular-ischaemic lesions, a normal spinal-cord examination can help rule out MS. Second, presence of asymptomatic spinal lesions may help confirm a diagnosis of MS when few or no brain lesions are present.

UR - http://www.scopus.com/inward/record.url?scp=0042521064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042521064&partnerID=8YFLogxK

U2 - 10.1016/S1474-4422(03)00504-0

DO - 10.1016/S1474-4422(03)00504-0

M3 - Article

VL - 2

SP - 555

EP - 562

JO - The Lancet Neurology

JF - The Lancet Neurology

SN - 1474-4422

IS - 9

ER -