Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children

Giorgio Perilongo, Marina Gardiman, Lucia Bisaglia, Luca Rigobello, Milena Calderone, Antonio Battistella, Roberta Burnelli, Felice Giangaspero

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: The aim of this study is to re-appraise paediatric leptomeningeal disseminated spinal low-grade neoplasms putting forward the hypothesis that these tumours may represent a possible distinctive clinico-pathological entity. Case report: Three children affected by these rare neoplasms are reported, 2 boys and 1 girl aged 40 months, 7 and 12 years respectively. Results: Despite treatment, 2 died at 9 months and 9 years, while 1 has survived with stable disease at 24 months after diagnosis. Histologically, these tumours shared the generic histological appearance of low-grade neuroectodermal neoplasms, without any features that allowed them to be included in a specific classification niche. The magnetic resonance imaging of the leptomeningeal dissemination took the form of a thick, diffuse subarachnoidal enhancement involving the brain as well the spine in 2 patients; in 1 patient there was an extensive enhancement along the surface of the brain and of the spinal cord and multiple small cysts, creating the impression of a diffuse microcystic meningoencephalopathy. Discussion: The patients described here and the similar ones found in the literature cannot be easily placed into the present WHO system of classification for central nervous system tumours.

Original languageEnglish
Pages (from-to)505-512
Number of pages8
JournalChild's Nervous System
Volume18
Issue number9-10
DOIs
Publication statusPublished - Oct 2002

Fingerprint

Neoplasms
Central Nervous System Neoplasms
Brain
Cysts
Spinal Cord
Spine
Magnetic Resonance Imaging
Pediatrics
Therapeutics

Keywords

  • Children
  • Leptomeningeal dissemination
  • Low-grade glioma
  • Spinal tumours

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Perilongo, G., Gardiman, M., Bisaglia, L., Rigobello, L., Calderone, M., Battistella, A., ... Giangaspero, F. (2002). Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children. Child's Nervous System, 18(9-10), 505-512. https://doi.org/10.1007/s00381-002-0626-8

Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children. / Perilongo, Giorgio; Gardiman, Marina; Bisaglia, Lucia; Rigobello, Luca; Calderone, Milena; Battistella, Antonio; Burnelli, Roberta; Giangaspero, Felice.

In: Child's Nervous System, Vol. 18, No. 9-10, 10.2002, p. 505-512.

Research output: Contribution to journalArticle

Perilongo, G, Gardiman, M, Bisaglia, L, Rigobello, L, Calderone, M, Battistella, A, Burnelli, R & Giangaspero, F 2002, 'Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children', Child's Nervous System, vol. 18, no. 9-10, pp. 505-512. https://doi.org/10.1007/s00381-002-0626-8
Perilongo G, Gardiman M, Bisaglia L, Rigobello L, Calderone M, Battistella A et al. Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children. Child's Nervous System. 2002 Oct;18(9-10):505-512. https://doi.org/10.1007/s00381-002-0626-8
Perilongo, Giorgio ; Gardiman, Marina ; Bisaglia, Lucia ; Rigobello, Luca ; Calderone, Milena ; Battistella, Antonio ; Burnelli, Roberta ; Giangaspero, Felice. / Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children. In: Child's Nervous System. 2002 ; Vol. 18, No. 9-10. pp. 505-512.
@article{4a2cadc536c54c8e9aa5bbf3ec7e770f,
title = "Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children",
abstract = "Objective: The aim of this study is to re-appraise paediatric leptomeningeal disseminated spinal low-grade neoplasms putting forward the hypothesis that these tumours may represent a possible distinctive clinico-pathological entity. Case report: Three children affected by these rare neoplasms are reported, 2 boys and 1 girl aged 40 months, 7 and 12 years respectively. Results: Despite treatment, 2 died at 9 months and 9 years, while 1 has survived with stable disease at 24 months after diagnosis. Histologically, these tumours shared the generic histological appearance of low-grade neuroectodermal neoplasms, without any features that allowed them to be included in a specific classification niche. The magnetic resonance imaging of the leptomeningeal dissemination took the form of a thick, diffuse subarachnoidal enhancement involving the brain as well the spine in 2 patients; in 1 patient there was an extensive enhancement along the surface of the brain and of the spinal cord and multiple small cysts, creating the impression of a diffuse microcystic meningoencephalopathy. Discussion: The patients described here and the similar ones found in the literature cannot be easily placed into the present WHO system of classification for central nervous system tumours.",
keywords = "Children, Leptomeningeal dissemination, Low-grade glioma, Spinal tumours",
author = "Giorgio Perilongo and Marina Gardiman and Lucia Bisaglia and Luca Rigobello and Milena Calderone and Antonio Battistella and Roberta Burnelli and Felice Giangaspero",
year = "2002",
month = "10",
doi = "10.1007/s00381-002-0626-8",
language = "English",
volume = "18",
pages = "505--512",
journal = "Child's Nervous System",
issn = "0256-7040",
publisher = "Springer Verlag",
number = "9-10",

}

TY - JOUR

T1 - Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children

AU - Perilongo, Giorgio

AU - Gardiman, Marina

AU - Bisaglia, Lucia

AU - Rigobello, Luca

AU - Calderone, Milena

AU - Battistella, Antonio

AU - Burnelli, Roberta

AU - Giangaspero, Felice

PY - 2002/10

Y1 - 2002/10

N2 - Objective: The aim of this study is to re-appraise paediatric leptomeningeal disseminated spinal low-grade neoplasms putting forward the hypothesis that these tumours may represent a possible distinctive clinico-pathological entity. Case report: Three children affected by these rare neoplasms are reported, 2 boys and 1 girl aged 40 months, 7 and 12 years respectively. Results: Despite treatment, 2 died at 9 months and 9 years, while 1 has survived with stable disease at 24 months after diagnosis. Histologically, these tumours shared the generic histological appearance of low-grade neuroectodermal neoplasms, without any features that allowed them to be included in a specific classification niche. The magnetic resonance imaging of the leptomeningeal dissemination took the form of a thick, diffuse subarachnoidal enhancement involving the brain as well the spine in 2 patients; in 1 patient there was an extensive enhancement along the surface of the brain and of the spinal cord and multiple small cysts, creating the impression of a diffuse microcystic meningoencephalopathy. Discussion: The patients described here and the similar ones found in the literature cannot be easily placed into the present WHO system of classification for central nervous system tumours.

AB - Objective: The aim of this study is to re-appraise paediatric leptomeningeal disseminated spinal low-grade neoplasms putting forward the hypothesis that these tumours may represent a possible distinctive clinico-pathological entity. Case report: Three children affected by these rare neoplasms are reported, 2 boys and 1 girl aged 40 months, 7 and 12 years respectively. Results: Despite treatment, 2 died at 9 months and 9 years, while 1 has survived with stable disease at 24 months after diagnosis. Histologically, these tumours shared the generic histological appearance of low-grade neuroectodermal neoplasms, without any features that allowed them to be included in a specific classification niche. The magnetic resonance imaging of the leptomeningeal dissemination took the form of a thick, diffuse subarachnoidal enhancement involving the brain as well the spine in 2 patients; in 1 patient there was an extensive enhancement along the surface of the brain and of the spinal cord and multiple small cysts, creating the impression of a diffuse microcystic meningoencephalopathy. Discussion: The patients described here and the similar ones found in the literature cannot be easily placed into the present WHO system of classification for central nervous system tumours.

KW - Children

KW - Leptomeningeal dissemination

KW - Low-grade glioma

KW - Spinal tumours

UR - http://www.scopus.com/inward/record.url?scp=0036817795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036817795&partnerID=8YFLogxK

U2 - 10.1007/s00381-002-0626-8

DO - 10.1007/s00381-002-0626-8

M3 - Article

C2 - 12382176

AN - SCOPUS:0036817795

VL - 18

SP - 505

EP - 512

JO - Child's Nervous System

JF - Child's Nervous System

SN - 0256-7040

IS - 9-10

ER -