Spinal Volumetric Bone Mineral Density and Vertebral Fractures in Female Patients with Adrenal Incidentalomas: The Effects of Subclinical Hypercortisolism and Gonadal Status

Research output: Contribution to journalArticle

Abstract

Although adrenal incidentalomas (AI) are not associated with clinically evident syndromes, some patients display biochemical features of subclinical hypercortisolism (SH). Previous studies indicated a negative effect of SH on bone in AI patients, but the prevalence of vertebral fractures and the roles of SH and gonadal status in volumetric bone mineral density are unknown. In 70 female AI patients and 84 controls, the prevalence of vertebral fractures and spinal bone mineral density (by quantitative computed tomography) were evaluated. Subjects were subdivided according to menopausal status into groups Pre (21 patients and 23 controls) and Post (49 patients and 61 controls); there were 14 and 35 patients without SH (SH-) and 7 and 14 patients with SH (SH+) in groups Pre and Post, respectively. The prevalence of fractures was higher in SH+ than in controls and in SH- subjects in both groups Pre [SH+, 42.9%; controls, 0% (P = 0.001); SH-, 7.1% (P = 0.049)] and post [SH+, 78.6%; controls, 37.7% (P = 0.006); SH- 42.9% (P = 0.024)]. In group Post, the mean z-score quantitative computed tomography values were lower in SH+ patients (-0.78 ± 0.29) than in controls (0.06 ± 0.14; P = 0.011) and SH- patients (0.02 ± 0.19; P = 0.034). Evaluation of spinal bone is indicated in female AI patients with SH.

Original languageEnglish
Pages (from-to)2237-2241
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number5
DOIs
Publication statusPublished - May 2004

Fingerprint

Cushing Syndrome
Bone Density
Minerals
Bone
Tomography
Adrenal incidentaloma
Spinal Fractures
Bone and Bones

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{7daeaa63c8e54fb398ad58f1a50e905f,
title = "Spinal Volumetric Bone Mineral Density and Vertebral Fractures in Female Patients with Adrenal Incidentalomas: The Effects of Subclinical Hypercortisolism and Gonadal Status",
abstract = "Although adrenal incidentalomas (AI) are not associated with clinically evident syndromes, some patients display biochemical features of subclinical hypercortisolism (SH). Previous studies indicated a negative effect of SH on bone in AI patients, but the prevalence of vertebral fractures and the roles of SH and gonadal status in volumetric bone mineral density are unknown. In 70 female AI patients and 84 controls, the prevalence of vertebral fractures and spinal bone mineral density (by quantitative computed tomography) were evaluated. Subjects were subdivided according to menopausal status into groups Pre (21 patients and 23 controls) and Post (49 patients and 61 controls); there were 14 and 35 patients without SH (SH-) and 7 and 14 patients with SH (SH+) in groups Pre and Post, respectively. The prevalence of fractures was higher in SH+ than in controls and in SH- subjects in both groups Pre [SH+, 42.9{\%}; controls, 0{\%} (P = 0.001); SH-, 7.1{\%} (P = 0.049)] and post [SH+, 78.6{\%}; controls, 37.7{\%} (P = 0.006); SH- 42.9{\%} (P = 0.024)]. In group Post, the mean z-score quantitative computed tomography values were lower in SH+ patients (-0.78 ± 0.29) than in controls (0.06 ± 0.14; P = 0.011) and SH- patients (0.02 ± 0.19; P = 0.034). Evaluation of spinal bone is indicated in female AI patients with SH.",
author = "Iacopo Chiodini and Giuseppe Guglielmi and Claudia Battista and Vincenzo Carnevale and Massimo Torlontano and Mario Cammisa and Vincenzo Trischitta and Alfredo Scillitani",
year = "2004",
month = "5",
doi = "10.1210/jc.2003-031413",
language = "English",
volume = "89",
pages = "2237--2241",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "5",

}

TY - JOUR

T1 - Spinal Volumetric Bone Mineral Density and Vertebral Fractures in Female Patients with Adrenal Incidentalomas

T2 - The Effects of Subclinical Hypercortisolism and Gonadal Status

AU - Chiodini, Iacopo

AU - Guglielmi, Giuseppe

AU - Battista, Claudia

AU - Carnevale, Vincenzo

AU - Torlontano, Massimo

AU - Cammisa, Mario

AU - Trischitta, Vincenzo

AU - Scillitani, Alfredo

PY - 2004/5

Y1 - 2004/5

N2 - Although adrenal incidentalomas (AI) are not associated with clinically evident syndromes, some patients display biochemical features of subclinical hypercortisolism (SH). Previous studies indicated a negative effect of SH on bone in AI patients, but the prevalence of vertebral fractures and the roles of SH and gonadal status in volumetric bone mineral density are unknown. In 70 female AI patients and 84 controls, the prevalence of vertebral fractures and spinal bone mineral density (by quantitative computed tomography) were evaluated. Subjects were subdivided according to menopausal status into groups Pre (21 patients and 23 controls) and Post (49 patients and 61 controls); there were 14 and 35 patients without SH (SH-) and 7 and 14 patients with SH (SH+) in groups Pre and Post, respectively. The prevalence of fractures was higher in SH+ than in controls and in SH- subjects in both groups Pre [SH+, 42.9%; controls, 0% (P = 0.001); SH-, 7.1% (P = 0.049)] and post [SH+, 78.6%; controls, 37.7% (P = 0.006); SH- 42.9% (P = 0.024)]. In group Post, the mean z-score quantitative computed tomography values were lower in SH+ patients (-0.78 ± 0.29) than in controls (0.06 ± 0.14; P = 0.011) and SH- patients (0.02 ± 0.19; P = 0.034). Evaluation of spinal bone is indicated in female AI patients with SH.

AB - Although adrenal incidentalomas (AI) are not associated with clinically evident syndromes, some patients display biochemical features of subclinical hypercortisolism (SH). Previous studies indicated a negative effect of SH on bone in AI patients, but the prevalence of vertebral fractures and the roles of SH and gonadal status in volumetric bone mineral density are unknown. In 70 female AI patients and 84 controls, the prevalence of vertebral fractures and spinal bone mineral density (by quantitative computed tomography) were evaluated. Subjects were subdivided according to menopausal status into groups Pre (21 patients and 23 controls) and Post (49 patients and 61 controls); there were 14 and 35 patients without SH (SH-) and 7 and 14 patients with SH (SH+) in groups Pre and Post, respectively. The prevalence of fractures was higher in SH+ than in controls and in SH- subjects in both groups Pre [SH+, 42.9%; controls, 0% (P = 0.001); SH-, 7.1% (P = 0.049)] and post [SH+, 78.6%; controls, 37.7% (P = 0.006); SH- 42.9% (P = 0.024)]. In group Post, the mean z-score quantitative computed tomography values were lower in SH+ patients (-0.78 ± 0.29) than in controls (0.06 ± 0.14; P = 0.011) and SH- patients (0.02 ± 0.19; P = 0.034). Evaluation of spinal bone is indicated in female AI patients with SH.

UR - http://www.scopus.com/inward/record.url?scp=2442455407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442455407&partnerID=8YFLogxK

U2 - 10.1210/jc.2003-031413

DO - 10.1210/jc.2003-031413

M3 - Article

C2 - 15126547

AN - SCOPUS:2442455407

VL - 89

SP - 2237

EP - 2241

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -