Spindle cell (kaposiform) hemangioendothelioma with Kasabach-Merritt syndrome in an infant: Successful treatment with α-2A interferon

G. Deb, A. Jenkner, L. De Sio, R. Boldrini, C. Bosman, N. Standoli, A. Donfrancesco

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A two-month-old infant developed a vascular tumor of the right flank which, upon biopsy, proved to be a spindle cell hemangioendothelioma. The increase capillary bed characterizing the neoplasm caused a severe thrombocytopenia together with a consumption coagulopathy (Kasabach Merritt syndrome). The patient, who was dependent on platelet transfusions, improved quickly after interferon α-2a was given at the dosage of 3.000,000 U/m2, with resolution of the Kasabach-Merritt syndrome after three weeks and a 75% decrease of the tumor volume within three months of treatment.

Original languageEnglish
Pages (from-to)358-361
Number of pages4
JournalMedical and Pediatric Oncology
Volume28
Issue number5
DOIs
Publication statusPublished - 1997

Fingerprint

Kasabach-Merritt Syndrome
Interferons
Hemangioendothelioma
Platelet Transfusion
Disseminated Intravascular Coagulation
Tumor Burden
Thrombocytopenia
Blood Vessels
Neoplasms
Biopsy
Therapeutics
Kaposiform Hemangioendothelioma

Keywords

  • hemangioendothelioma
  • interferon α-2a treatment
  • Kasabach-Merritt syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Spindle cell (kaposiform) hemangioendothelioma with Kasabach-Merritt syndrome in an infant : Successful treatment with α-2A interferon. / Deb, G.; Jenkner, A.; De Sio, L.; Boldrini, R.; Bosman, C.; Standoli, N.; Donfrancesco, A.

In: Medical and Pediatric Oncology, Vol. 28, No. 5, 1997, p. 358-361.

Research output: Contribution to journalArticle

@article{7f4e266539244254a3ec2f1060c46b20,
title = "Spindle cell (kaposiform) hemangioendothelioma with Kasabach-Merritt syndrome in an infant: Successful treatment with α-2A interferon",
abstract = "A two-month-old infant developed a vascular tumor of the right flank which, upon biopsy, proved to be a spindle cell hemangioendothelioma. The increase capillary bed characterizing the neoplasm caused a severe thrombocytopenia together with a consumption coagulopathy (Kasabach Merritt syndrome). The patient, who was dependent on platelet transfusions, improved quickly after interferon α-2a was given at the dosage of 3.000,000 U/m2, with resolution of the Kasabach-Merritt syndrome after three weeks and a 75{\%} decrease of the tumor volume within three months of treatment.",
keywords = "hemangioendothelioma, interferon α-2a treatment, Kasabach-Merritt syndrome",
author = "G. Deb and A. Jenkner and {De Sio}, L. and R. Boldrini and C. Bosman and N. Standoli and A. Donfrancesco",
year = "1997",
doi = "10.1002/(SICI)1096-911X(199705)28:5<358::AID-MPO6>3.0.CO;2-G",
language = "English",
volume = "28",
pages = "358--361",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Spindle cell (kaposiform) hemangioendothelioma with Kasabach-Merritt syndrome in an infant

T2 - Successful treatment with α-2A interferon

AU - Deb, G.

AU - Jenkner, A.

AU - De Sio, L.

AU - Boldrini, R.

AU - Bosman, C.

AU - Standoli, N.

AU - Donfrancesco, A.

PY - 1997

Y1 - 1997

N2 - A two-month-old infant developed a vascular tumor of the right flank which, upon biopsy, proved to be a spindle cell hemangioendothelioma. The increase capillary bed characterizing the neoplasm caused a severe thrombocytopenia together with a consumption coagulopathy (Kasabach Merritt syndrome). The patient, who was dependent on platelet transfusions, improved quickly after interferon α-2a was given at the dosage of 3.000,000 U/m2, with resolution of the Kasabach-Merritt syndrome after three weeks and a 75% decrease of the tumor volume within three months of treatment.

AB - A two-month-old infant developed a vascular tumor of the right flank which, upon biopsy, proved to be a spindle cell hemangioendothelioma. The increase capillary bed characterizing the neoplasm caused a severe thrombocytopenia together with a consumption coagulopathy (Kasabach Merritt syndrome). The patient, who was dependent on platelet transfusions, improved quickly after interferon α-2a was given at the dosage of 3.000,000 U/m2, with resolution of the Kasabach-Merritt syndrome after three weeks and a 75% decrease of the tumor volume within three months of treatment.

KW - hemangioendothelioma

KW - interferon α-2a treatment

KW - Kasabach-Merritt syndrome

UR - http://www.scopus.com/inward/record.url?scp=0030894488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030894488&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1096-911X(199705)28:5<358::AID-MPO6>3.0.CO;2-G

DO - 10.1002/(SICI)1096-911X(199705)28:5<358::AID-MPO6>3.0.CO;2-G

M3 - Article

C2 - 9121401

AN - SCOPUS:0030894488

VL - 28

SP - 358

EP - 361

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 5

ER -