Spindle cell (kaposiform) hemangioendothelioma with Kasabach-Merritt syndrome in an infant: Successful treatment with α-2A interferon

G. Deb, A. Jenkner, L. De Sio, R. Boldrini, C. Bosman, N. Standoli, A. Donfrancesco

Research output: Contribution to journalArticle

Abstract

A two-month-old infant developed a vascular tumor of the right flank which, upon biopsy, proved to be a spindle cell hemangioendothelioma. The increase capillary bed characterizing the neoplasm caused a severe thrombocytopenia together with a consumption coagulopathy (Kasabach Merritt syndrome). The patient, who was dependent on platelet transfusions, improved quickly after interferon α-2a was given at the dosage of 3.000,000 U/m2, with resolution of the Kasabach-Merritt syndrome after three weeks and a 75% decrease of the tumor volume within three months of treatment.

Original languageEnglish
Pages (from-to)358-361
Number of pages4
JournalMedical and Pediatric Oncology
Volume28
Issue number5
DOIs
Publication statusPublished - 1997

Keywords

  • hemangioendothelioma
  • interferon α-2a treatment
  • Kasabach-Merritt syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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