Spindle-cell squamous carcinoma of head and neck region: A clinicopathologic and immunohistochemical study of eight cases

E. Leonardi, P. Dalri, T. Pusiol, R. Valdagni, F. Piscioli

Research output: Contribution to journalArticlepeer-review

Abstract

Spindle cell squamous carcinoma is a highly malignant neoplasm, characterized by a biphasic appearance, due to the presence of a diffuse proliferative pattern of pleomorphic spindle cells with extremely rare foci of conventional squamous cell carcinoma. Epithelial markers in eight cases of spindle-cell squamous carcinoma of the head and neck region were studied by immunocytochemistry. Epithelial membrane antigen and cytokeratin resulted strongly positive in the spindle cells of the sarcoma-like areas demonstrating the epithelial nature of the neoplasm. In 6 of our patients who later died from widespread metastases, the neoplasm had poor prognosis with a mean survival rate of 14.7 months.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalORL
Volume48
Issue number5
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Otorhinolaryngology

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