Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landau-Kleffner syndrome

L. Nobili, M. G. Baglietto, M. Beelke, F. De Carli, E. De Negri, S. Tortorelli, F. Ferrillo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purpose: Landau-Kleffner syndrome (LKS) is characterized by a marked increase of interictal epileptiform discharges (IEDs) during sleep. During nonrapid eye movement (NREM) sleep, neuronal membrane potential oscillations lead to the appearance of spindles and delta waves in the surface EEG and might develop into paroxysmal synchronization. Spectral analysis allows the quantitative description of the dynamics of delta (slow-wave activity, SWA, 0.5-4.5 Hz) and sigma activity (SA, 12.0-16.0 Hz) and can be used to assess the relation between SA, SWA, and IEDs during sleep. Methods: We performed six overnight continuous EEG-polysomnographic studies in three patients with LKS. The temporal series of SWA and SA were obtained from a spike-free derivation lead. The IEDs count was performed on the most active lead. Relations between sigma and SWA and time series of IEDs were tested by means of correlation techniques after data normalization. Results: Our results revealed a significantly higher correlation between IEDs and SA with respect to SWA in all the subjects, in total sleep time. The same analysis limited to NREM sleep highlights the better correlation between SA and IEDs. Conclusions: Our data suggest that neural mechanisms involved in the generation of sleep spindles facilitate IEDs production in LKS.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalEpilepsia
Volume41
Issue number2
Publication statusPublished - 2000

Fingerprint

Landau-Kleffner Syndrome
Sleep
Eye Movements
Electroencephalography
Membrane Potentials

Keywords

  • Interictal epileptic discharges
  • Landau-Kleffner syndrome
  • Sleep
  • Slow-wave activity
  • Spindles

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Nobili, L., Baglietto, M. G., Beelke, M., De Carli, F., De Negri, E., Tortorelli, S., & Ferrillo, F. (2000). Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landau-Kleffner syndrome. Epilepsia, 41(2), 201-206.

Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landau-Kleffner syndrome. / Nobili, L.; Baglietto, M. G.; Beelke, M.; De Carli, F.; De Negri, E.; Tortorelli, S.; Ferrillo, F.

In: Epilepsia, Vol. 41, No. 2, 2000, p. 201-206.

Research output: Contribution to journalArticle

Nobili, L, Baglietto, MG, Beelke, M, De Carli, F, De Negri, E, Tortorelli, S & Ferrillo, F 2000, 'Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landau-Kleffner syndrome', Epilepsia, vol. 41, no. 2, pp. 201-206.
Nobili L, Baglietto MG, Beelke M, De Carli F, De Negri E, Tortorelli S et al. Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landau-Kleffner syndrome. Epilepsia. 2000;41(2):201-206.
Nobili, L. ; Baglietto, M. G. ; Beelke, M. ; De Carli, F. ; De Negri, E. ; Tortorelli, S. ; Ferrillo, F. / Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landau-Kleffner syndrome. In: Epilepsia. 2000 ; Vol. 41, No. 2. pp. 201-206.
@article{e29a433d7e46415390115c878ff52a80,
title = "Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landau-Kleffner syndrome",
abstract = "Purpose: Landau-Kleffner syndrome (LKS) is characterized by a marked increase of interictal epileptiform discharges (IEDs) during sleep. During nonrapid eye movement (NREM) sleep, neuronal membrane potential oscillations lead to the appearance of spindles and delta waves in the surface EEG and might develop into paroxysmal synchronization. Spectral analysis allows the quantitative description of the dynamics of delta (slow-wave activity, SWA, 0.5-4.5 Hz) and sigma activity (SA, 12.0-16.0 Hz) and can be used to assess the relation between SA, SWA, and IEDs during sleep. Methods: We performed six overnight continuous EEG-polysomnographic studies in three patients with LKS. The temporal series of SWA and SA were obtained from a spike-free derivation lead. The IEDs count was performed on the most active lead. Relations between sigma and SWA and time series of IEDs were tested by means of correlation techniques after data normalization. Results: Our results revealed a significantly higher correlation between IEDs and SA with respect to SWA in all the subjects, in total sleep time. The same analysis limited to NREM sleep highlights the better correlation between SA and IEDs. Conclusions: Our data suggest that neural mechanisms involved in the generation of sleep spindles facilitate IEDs production in LKS.",
keywords = "Interictal epileptic discharges, Landau-Kleffner syndrome, Sleep, Slow-wave activity, Spindles",
author = "L. Nobili and Baglietto, {M. G.} and M. Beelke and {De Carli}, F. and {De Negri}, E. and S. Tortorelli and F. Ferrillo",
year = "2000",
language = "English",
volume = "41",
pages = "201--206",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Blackwell Publishing Inc.",
number = "2",

}

TY - JOUR

T1 - Spindles-inducing mechanism modulates sleep activation of interictal epileptiform discharges in the Landau-Kleffner syndrome

AU - Nobili, L.

AU - Baglietto, M. G.

AU - Beelke, M.

AU - De Carli, F.

AU - De Negri, E.

AU - Tortorelli, S.

AU - Ferrillo, F.

PY - 2000

Y1 - 2000

N2 - Purpose: Landau-Kleffner syndrome (LKS) is characterized by a marked increase of interictal epileptiform discharges (IEDs) during sleep. During nonrapid eye movement (NREM) sleep, neuronal membrane potential oscillations lead to the appearance of spindles and delta waves in the surface EEG and might develop into paroxysmal synchronization. Spectral analysis allows the quantitative description of the dynamics of delta (slow-wave activity, SWA, 0.5-4.5 Hz) and sigma activity (SA, 12.0-16.0 Hz) and can be used to assess the relation between SA, SWA, and IEDs during sleep. Methods: We performed six overnight continuous EEG-polysomnographic studies in three patients with LKS. The temporal series of SWA and SA were obtained from a spike-free derivation lead. The IEDs count was performed on the most active lead. Relations between sigma and SWA and time series of IEDs were tested by means of correlation techniques after data normalization. Results: Our results revealed a significantly higher correlation between IEDs and SA with respect to SWA in all the subjects, in total sleep time. The same analysis limited to NREM sleep highlights the better correlation between SA and IEDs. Conclusions: Our data suggest that neural mechanisms involved in the generation of sleep spindles facilitate IEDs production in LKS.

AB - Purpose: Landau-Kleffner syndrome (LKS) is characterized by a marked increase of interictal epileptiform discharges (IEDs) during sleep. During nonrapid eye movement (NREM) sleep, neuronal membrane potential oscillations lead to the appearance of spindles and delta waves in the surface EEG and might develop into paroxysmal synchronization. Spectral analysis allows the quantitative description of the dynamics of delta (slow-wave activity, SWA, 0.5-4.5 Hz) and sigma activity (SA, 12.0-16.0 Hz) and can be used to assess the relation between SA, SWA, and IEDs during sleep. Methods: We performed six overnight continuous EEG-polysomnographic studies in three patients with LKS. The temporal series of SWA and SA were obtained from a spike-free derivation lead. The IEDs count was performed on the most active lead. Relations between sigma and SWA and time series of IEDs were tested by means of correlation techniques after data normalization. Results: Our results revealed a significantly higher correlation between IEDs and SA with respect to SWA in all the subjects, in total sleep time. The same analysis limited to NREM sleep highlights the better correlation between SA and IEDs. Conclusions: Our data suggest that neural mechanisms involved in the generation of sleep spindles facilitate IEDs production in LKS.

KW - Interictal epileptic discharges

KW - Landau-Kleffner syndrome

KW - Sleep

KW - Slow-wave activity

KW - Spindles

UR - http://www.scopus.com/inward/record.url?scp=0033952777&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033952777&partnerID=8YFLogxK

M3 - Article

C2 - 10691117

AN - SCOPUS:0033952777

VL - 41

SP - 201

EP - 206

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 2

ER -