Spine Bone Texture Assessed by Trabecular Bone Score (TBS) to Evaluate Bone Health in Thalassemia Major

M. Baldini, F. M. Ulivieri, S. Forti, S. Serafino, S. Seghezzi, A. Marcon, F. Giarda, C. Messina, E. Cassinerio, B. Aubry-Rozier, D. Hans, M. D. Cappellini

Research output: Contribution to journalArticlepeer-review

Abstract

Due to the increasing survival of thalassemic patients, osteopathy is a mounting clinical problem. Low bone mass alone cannot account for the high fracture risk described; impaired bone quality has been speculated but so far it cannot be demonstrated noninvasively. We studied bone quality in thalassemia major using trabecular bone score (TBS), a novel texture measurement extracted from spine dual-energy X-ray absorptiometry (DXA), proposed in postmenopausal and secondary osteoporosis as an indirect index of microarchitecture. TBS was evaluated in 124 adult thalassemics (age range 19–56 years), followed-up with optimal transfusional and therapeutical regimens, and in 65 non-thalassemic patients (22–52 years) undergoing DXA for different bone diseases. TBS was lower in thalassemic patients (1.04 ± 0.12 [range 0.80–1.30]) versus controls (1.34 ± 0.11 [1.06–1.52]) (p 

Original languageEnglish
Pages (from-to)540-546
Number of pages7
JournalCalcified Tissue International
Volume95
Issue number6
DOIs
Publication statusPublished - Nov 21 2014

Keywords

  • Osteoporosis
  • Thalassemia major
  • Trabecular bone score

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Medicine(all)

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