The Spitz–Reed nevi family includes benign melanocytic tumors, generally acquired, characterized by a wide variety of clinical presentations, dermoscopic pattern and histopathologic features. The clinical differential diagnosis with melanoma is often considered due to its alarming clinical presentation. Spitz nevi are often described as pinkish-red papule suddenly arising in very young people, whereas Reed ones are commonly seen on the legs of adult patients. In both cases, patients often refer that the lesion suddenly appeared and is quickly growing. In this chapter, and often in the daily clinical experience, these two entities are joined in the same group, showing common histopathologic findings.
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