Spitz nevi: In vivo confocal microscopic features, dermatoscopic aspects, histopathologic correlates, and diagnostic significance

Giovanni Pellacani, Caterina Longo, Gerardo Ferrara, Anna Maria Cesinaro, Sara Bassoli, Pascale Guitera, Scott W. Menzies, Stefania Seidenari

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Spitz nevi are benign melanocytic tumors, sometimes misdiagnosed as malignant melanoma (MM). Objective: We sought identification of characteristic in vivo microscopic features of Spitz nevi, their histopathologic correlates, and diagnostic usefulness. Methods: Forty Spitz nevi were studied by in vivo confocal microscopy and dermatoscopy, evaluating histopathologic correlates, and compared with 40 MMs and 40 Clark nevi. Results: Some histologic aspects characteristic for Spitz nevus diagnosis were correlated with confocal features, comprising some that can be useful for atypical Spitz nevus classification. The most striking features for differentiating Spitz nevi from MMs were the presence of sharp border cut-off, junctional nests, and melanophages. Limitations: No correlates were found for other aspects, such as Kamino bodies, hyperkeratosis, acanthosis, mitoses, and maturation with depth. The impossibility of exploring deeper aspects hampered an accurate distinction from MMs in some cases. Conclusion: Confocal and dermatoscopic examination enabled the identification of different Spitz categories with different histologic substrates.

Original languageEnglish
Pages (from-to)236-247
Number of pages12
JournalJournal of the American Academy of Dermatology
Volume60
Issue number2
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Epithelioid and Spindle Cell Nevus
Dermoscopy
Nevus
Diagnostic Errors
Mitosis
Confocal Microscopy
Melanoma

ASJC Scopus subject areas

  • Dermatology

Cite this

Spitz nevi : In vivo confocal microscopic features, dermatoscopic aspects, histopathologic correlates, and diagnostic significance. / Pellacani, Giovanni; Longo, Caterina; Ferrara, Gerardo; Cesinaro, Anna Maria; Bassoli, Sara; Guitera, Pascale; Menzies, Scott W.; Seidenari, Stefania.

In: Journal of the American Academy of Dermatology, Vol. 60, No. 2, 02.2009, p. 236-247.

Research output: Contribution to journalArticle

Pellacani, Giovanni ; Longo, Caterina ; Ferrara, Gerardo ; Cesinaro, Anna Maria ; Bassoli, Sara ; Guitera, Pascale ; Menzies, Scott W. ; Seidenari, Stefania. / Spitz nevi : In vivo confocal microscopic features, dermatoscopic aspects, histopathologic correlates, and diagnostic significance. In: Journal of the American Academy of Dermatology. 2009 ; Vol. 60, No. 2. pp. 236-247.
@article{3a6dcb9f1bbf46eeb65cfff8b41a34cc,
title = "Spitz nevi: In vivo confocal microscopic features, dermatoscopic aspects, histopathologic correlates, and diagnostic significance",
abstract = "Background: Spitz nevi are benign melanocytic tumors, sometimes misdiagnosed as malignant melanoma (MM). Objective: We sought identification of characteristic in vivo microscopic features of Spitz nevi, their histopathologic correlates, and diagnostic usefulness. Methods: Forty Spitz nevi were studied by in vivo confocal microscopy and dermatoscopy, evaluating histopathologic correlates, and compared with 40 MMs and 40 Clark nevi. Results: Some histologic aspects characteristic for Spitz nevus diagnosis were correlated with confocal features, comprising some that can be useful for atypical Spitz nevus classification. The most striking features for differentiating Spitz nevi from MMs were the presence of sharp border cut-off, junctional nests, and melanophages. Limitations: No correlates were found for other aspects, such as Kamino bodies, hyperkeratosis, acanthosis, mitoses, and maturation with depth. The impossibility of exploring deeper aspects hampered an accurate distinction from MMs in some cases. Conclusion: Confocal and dermatoscopic examination enabled the identification of different Spitz categories with different histologic substrates.",
author = "Giovanni Pellacani and Caterina Longo and Gerardo Ferrara and Cesinaro, {Anna Maria} and Sara Bassoli and Pascale Guitera and Menzies, {Scott W.} and Stefania Seidenari",
year = "2009",
month = "2",
doi = "10.1016/j.jaad.2008.07.061",
language = "English",
volume = "60",
pages = "236--247",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Spitz nevi

T2 - In vivo confocal microscopic features, dermatoscopic aspects, histopathologic correlates, and diagnostic significance

AU - Pellacani, Giovanni

AU - Longo, Caterina

AU - Ferrara, Gerardo

AU - Cesinaro, Anna Maria

AU - Bassoli, Sara

AU - Guitera, Pascale

AU - Menzies, Scott W.

AU - Seidenari, Stefania

PY - 2009/2

Y1 - 2009/2

N2 - Background: Spitz nevi are benign melanocytic tumors, sometimes misdiagnosed as malignant melanoma (MM). Objective: We sought identification of characteristic in vivo microscopic features of Spitz nevi, their histopathologic correlates, and diagnostic usefulness. Methods: Forty Spitz nevi were studied by in vivo confocal microscopy and dermatoscopy, evaluating histopathologic correlates, and compared with 40 MMs and 40 Clark nevi. Results: Some histologic aspects characteristic for Spitz nevus diagnosis were correlated with confocal features, comprising some that can be useful for atypical Spitz nevus classification. The most striking features for differentiating Spitz nevi from MMs were the presence of sharp border cut-off, junctional nests, and melanophages. Limitations: No correlates were found for other aspects, such as Kamino bodies, hyperkeratosis, acanthosis, mitoses, and maturation with depth. The impossibility of exploring deeper aspects hampered an accurate distinction from MMs in some cases. Conclusion: Confocal and dermatoscopic examination enabled the identification of different Spitz categories with different histologic substrates.

AB - Background: Spitz nevi are benign melanocytic tumors, sometimes misdiagnosed as malignant melanoma (MM). Objective: We sought identification of characteristic in vivo microscopic features of Spitz nevi, their histopathologic correlates, and diagnostic usefulness. Methods: Forty Spitz nevi were studied by in vivo confocal microscopy and dermatoscopy, evaluating histopathologic correlates, and compared with 40 MMs and 40 Clark nevi. Results: Some histologic aspects characteristic for Spitz nevus diagnosis were correlated with confocal features, comprising some that can be useful for atypical Spitz nevus classification. The most striking features for differentiating Spitz nevi from MMs were the presence of sharp border cut-off, junctional nests, and melanophages. Limitations: No correlates were found for other aspects, such as Kamino bodies, hyperkeratosis, acanthosis, mitoses, and maturation with depth. The impossibility of exploring deeper aspects hampered an accurate distinction from MMs in some cases. Conclusion: Confocal and dermatoscopic examination enabled the identification of different Spitz categories with different histologic substrates.

UR - http://www.scopus.com/inward/record.url?scp=58149520144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149520144&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2008.07.061

DO - 10.1016/j.jaad.2008.07.061

M3 - Article

C2 - 19091443

AN - SCOPUS:58149520144

VL - 60

SP - 236

EP - 247

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 2

ER -