Spitz nevus of the tongue with pseudoepitheliomatous hyperplasia: Report of three cases of a pseudomalignant condition

Tshering Dorji, Alberto Cavazza, Oscar Nappi, Juan Rosai

Research output: Contribution to journalArticle

Abstract

Three cases of Spitz nevus of the tongue associated with pseudoepitheliomatous hyperplasia are reported: two occurring in children and one in an adult. The location at an unusual site and the complex pattern resulting from the intimate admixture of the neoplastic melanocytic component and the hyperplastic keratinocytic component led in each case to consider diagnoses such as malignant melanoma and invasive squamous cell carcinoma. Staining for S-100 protein and keratin was useful to identify and separate the two components. Spitz nevus of the tongue carries some intriguing similarities with granular cell tumor, suggesting a possible histogenetic and pathogenetic relationship.

Original languageEnglish
Pages (from-to)774-777
Number of pages4
JournalAmerican Journal of Surgical Pathology
Volume26
Issue number6
DOIs
Publication statusPublished - 2002

Keywords

  • Pseudoepitheliomatous hyperplasia
  • Spitz nevus
  • Tongue

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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