Spitz Nevus, Spitz Tumor, and Spitzoid Melanoma. A Comprehensive Clinicopathologic Overview.

Gerardo Ferrara, Raffaele Gianotti, Stefano Cavicchini, Tiziana Salviato, Iris Zalaudek, Giuseppe Argenziano

Research output: Contribution to journalArticlepeer-review


Spitz nevus can clinically present either in the classical (reddish pink) or the pigmented (brownish black) variant. Dermoscopy demonstrates that the pigmented variant is much more common than the classical variant; however, none of these show dermoscopic patterns clearly distinguishable from melanoma. Even histopathologically, a clear-cut differentiation between benign and malignant spitzoid neoplasms is often difficult, so that intermediate diagnostic categories (atypical Spitz nevus and Spitz tumor) are admitted. Because of these difficulties in clinical and histopathologic evaluation, surgical excision is recommended for clinically atypical spitzoid lesions of childhood and for all spitzoid lesions of adulthood.

Original languageEnglish
Pages (from-to)589-598
Number of pages10
JournalDermatologic Clinics
Issue number4
Publication statusPublished - Oct 2013


  • Atypical Spitz nevus
  • Dermoscopy
  • Histopathology
  • Spitz nevus
  • Spitz tumor
  • Spitzoid melanoma

ASJC Scopus subject areas

  • Dermatology


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