Splenectomy in children with chronic ITP: Long-term efficacy and relation between its outcome and responses to previous treatments

Ugo Ramenghi, Giovanni Amendola, Loredana Farinasso, Paola Giordano, Giuseppe Loffredo, Bruno Nobili, Silverio Perrotta, Giovanna Russo, Marco Zecca

Research output: Contribution to journalArticlepeer-review

Abstract

This retrospective study was conducted to determine whether the response to splenectomy is related to the response to previous treatments. We examined the records of 90 children splenectomized for chronic ITP. Platelet counts were constantly >50 × 10 9/L in 68 patients (75%). An improvement in the quality of life was observed in 79 (85%). The success of splenectomy was strongly correlated with a good response to previous treatment. A negative response to any of the prior treatments had no predictive value. This finding is relevant when elective splenectomy is considered as a treatment option.

Original languageEnglish
Pages (from-to)742-745
Number of pages4
JournalPediatric Blood and Cancer
Volume47
Issue number5 SUPPL.
DOIs
Publication statusPublished - Oct 15 2006

Keywords

  • Immunoglobulins
  • Splenectomy
  • Thrombocytopenic purpura

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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