Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia: Update of a prospective randomized study

A. Gratwohl, J. Hermans, A. V. Biezen, W. Arcese, T. De Witte, L. Debusscher, P. Ernst, A. Ferrant, F. Frassoni, G. Gahrton, A. Iriondo, H. J. Kolb, H. Link, D. Niederwieser, T. Ruutu, N. Schmitz, W. Siegert, A. Torres-Gomez, J. P. Vernant, F. E. Zwaan

Research output: Contribution to journalArticle

Abstract

Two hundred and twenty-nine patients with chronic myeloid leukaemia in chronic phase awaiting bone marrow transplantation from an HLA-identical sibling donor were randomized as part of their conditioning, to receive splenic irradiation (SI+ 115 patients), or not (SI-, 114 patients). Both groups were identical in regard to age, sex, donor/recipient sex combination and disease activity. Survival, leukaemia-free survival, incidence of transplant-related mortality, acute and chronic graft versus host disease, incidence of rejection and probability of relapse were not different in either groups at a median follow-up time of 4.5 years (minimum follow-up 2 years). Recovery of peripheral white blood cell counts to 1 × 109/1 but not of platelet counts to 50 × 109/1 was significantly faster in patients with SI+ (21 vs 24 days). This small benefit does not justify routine splenic irradiation prior to BMT, in CML.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalLeukemia and Lymphoma
Volume11
Issue numbers1
DOIs
Publication statusPublished - 1993

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Bone Marrow Transplantation
Prospective Studies
Tissue Donors
Leukemia, Myeloid, Chronic Phase
Survival
Incidence
Graft vs Host Disease
Platelet Count
Leukocyte Count
Siblings
Leukemia
Transplants
Recurrence
Mortality

Keywords

  • BMT
  • CML
  • Splenic irradiation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Gratwohl, A., Hermans, J., Biezen, A. V., Arcese, W., Witte, T. D., Debusscher, L., ... Zwaan, F. E. (1993). Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia: Update of a prospective randomized study. Leukemia and Lymphoma, 11(s1), 227-231. https://doi.org/10.3109/10428199309047891

Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia : Update of a prospective randomized study. / Gratwohl, A.; Hermans, J.; Biezen, A. V.; Arcese, W.; Witte, T. De; Debusscher, L.; Ernst, P.; Ferrant, A.; Frassoni, F.; Gahrton, G.; Iriondo, A.; Kolb, H. J.; Link, H.; Niederwieser, D.; Ruutu, T.; Schmitz, N.; Siegert, W.; Torres-Gomez, A.; Vernant, J. P.; Zwaan, F. E.

In: Leukemia and Lymphoma, Vol. 11, No. s1, 1993, p. 227-231.

Research output: Contribution to journalArticle

Gratwohl, A, Hermans, J, Biezen, AV, Arcese, W, Witte, TD, Debusscher, L, Ernst, P, Ferrant, A, Frassoni, F, Gahrton, G, Iriondo, A, Kolb, HJ, Link, H, Niederwieser, D, Ruutu, T, Schmitz, N, Siegert, W, Torres-Gomez, A, Vernant, JP & Zwaan, FE 1993, 'Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia: Update of a prospective randomized study', Leukemia and Lymphoma, vol. 11, no. s1, pp. 227-231. https://doi.org/10.3109/10428199309047891
Gratwohl, A. ; Hermans, J. ; Biezen, A. V. ; Arcese, W. ; Witte, T. De ; Debusscher, L. ; Ernst, P. ; Ferrant, A. ; Frassoni, F. ; Gahrton, G. ; Iriondo, A. ; Kolb, H. J. ; Link, H. ; Niederwieser, D. ; Ruutu, T. ; Schmitz, N. ; Siegert, W. ; Torres-Gomez, A. ; Vernant, J. P. ; Zwaan, F. E. / Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia : Update of a prospective randomized study. In: Leukemia and Lymphoma. 1993 ; Vol. 11, No. s1. pp. 227-231.
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