Splenomegalic immunocytoma with circulating hairy cells. Report of eight cases and revision of the literature

P. Spriano, G. Barosi, R. Invernizzi, G. Ippoliti, A. Fortunato, R. Rosso, U. Magrini

Research output: Contribution to journalArticlepeer-review

Abstract

Eight cases of lymphoplasmacytoid lymphoma (immunocytoma) with peculiar features are presented and 28 similar cases reported in the literature are reviewed. The cases were characterized by the following picture: isolated splenomegaly without lymph node enlargment, presence of atypical lymphoid cells with a hairy appearance and TRAP positivity in peripheral blood, constant gammopathy and nodular lymphoplasmacytoid proliferation especially in the spleen. The polymorphic presentation as well as the peculiar immunologic, histologic and immunohistochemical features separate this group from other malignant splenic lymphomas. The clinical and haematological improvement after splenectomy and the more favourable follow up in splenectomized patients suggests splenectomy as an elective therapy of the disease.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalHaematologica
Volume71
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Splenomegalic immunocytoma with circulating hairy cells. Report of eight cases and revision of the literature'. Together they form a unique fingerprint.

Cite this