Splicing regulation in brain and testis: common themes for highly specialized organs

Chiara Naro; Eleonora Cesari; Claudio Sette

doi:10.1080/15384101.2021.1889187

Splicing regulation in brain and testis: common themes for highly specialized organs

Chiara Naro, Eleonora Cesari, Claudio Sette

Research output: Contribution to journal › Review article › peer-review

Abstract

Expansion of the coding and regulatory capabilities of eukaryotic transcriptomes by alternative splicing represents one of the evolutionary forces underlying the increased structural complexity of metazoans. Brain and testes stand out as the organs that mostly exploit the potential of alternative splicing, thereby expressing the largest repertoire of splice variants. Herein, we will review organ-specific as well as common mechanisms underlying the high transcriptome complexity of these organs and discuss the impact exerted by this widespread alternative splicing regulation on the functionality and differentiation of brain and testicular cells.

Original language	English
Pages (from-to)	480-489
Number of pages	10
Journal	Cell Cycle
Volume	20
Issue number	5-6
DOIs	https://doi.org/10.1080/15384101.2021.1889187
Publication status	Published - 2021

Keywords

alternative splicing
Brain
neuron differentiation
spermatogenesis
testis
transcriptomics

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.1080/15384101.2021.1889187

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title = "Splicing regulation in brain and testis: common themes for highly specialized organs",

abstract = "Expansion of the coding and regulatory capabilities of eukaryotic transcriptomes by alternative splicing represents one of the evolutionary forces underlying the increased structural complexity of metazoans. Brain and testes stand out as the organs that mostly exploit the potential of alternative splicing, thereby expressing the largest repertoire of splice variants. Herein, we will review organ-specific as well as common mechanisms underlying the high transcriptome complexity of these organs and discuss the impact exerted by this widespread alternative splicing regulation on the functionality and differentiation of brain and testicular cells.",

keywords = "alternative splicing, Brain, neuron differentiation, spermatogenesis, testis, transcriptomics",

author = "Chiara Naro and Eleonora Cesari and Claudio Sette",

note = "Funding Information: We thank Dr Donatella Farini for critical discussions. C.N. was supported by a fellowship from Fondazione Umberto Veronesi. Funding Information: This work was supported by the Associazione Italiana per la Ricerca sul Cancro [IG23416]; Ministero dell?Istruzione, dell?Universit? [PRIN 2017 2017P352]. Universit? Cattolica del Sacro Cuore contributed to the funding of this research project and its publication. We thank Dr Donatella Farini for critical discussions. C.N. was supported by a fellowship from Fondazione Umberto Veronesi. Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor & Francis Group. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

doi = "10.1080/15384101.2021.1889187",

language = "English",

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T2 - common themes for highly specialized organs

AU - Naro, Chiara

AU - Cesari, Eleonora

AU - Sette, Claudio

N1 - Funding Information: We thank Dr Donatella Farini for critical discussions. C.N. was supported by a fellowship from Fondazione Umberto Veronesi. Funding Information: This work was supported by the Associazione Italiana per la Ricerca sul Cancro [IG23416]; Ministero dell?Istruzione, dell?Universit? [PRIN 2017 2017P352]. Universit? Cattolica del Sacro Cuore contributed to the funding of this research project and its publication. We thank Dr Donatella Farini for critical discussions. C.N. was supported by a fellowship from Fondazione Umberto Veronesi. Publisher Copyright: © 2021 Informa UK Limited, trading as Taylor & Francis Group. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - Expansion of the coding and regulatory capabilities of eukaryotic transcriptomes by alternative splicing represents one of the evolutionary forces underlying the increased structural complexity of metazoans. Brain and testes stand out as the organs that mostly exploit the potential of alternative splicing, thereby expressing the largest repertoire of splice variants. Herein, we will review organ-specific as well as common mechanisms underlying the high transcriptome complexity of these organs and discuss the impact exerted by this widespread alternative splicing regulation on the functionality and differentiation of brain and testicular cells.

AB - Expansion of the coding and regulatory capabilities of eukaryotic transcriptomes by alternative splicing represents one of the evolutionary forces underlying the increased structural complexity of metazoans. Brain and testes stand out as the organs that mostly exploit the potential of alternative splicing, thereby expressing the largest repertoire of splice variants. Herein, we will review organ-specific as well as common mechanisms underlying the high transcriptome complexity of these organs and discuss the impact exerted by this widespread alternative splicing regulation on the functionality and differentiation of brain and testicular cells.

KW - alternative splicing

KW - Brain

KW - neuron differentiation

KW - spermatogenesis

KW - testis

KW - transcriptomics

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JF - Cell Cycle

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ER -

Splicing regulation in brain and testis: common themes for highly specialized organs

Abstract

Keywords

ASJC Scopus subject areas

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