Abstract
Expansion of the coding and regulatory capabilities of eukaryotic transcriptomes by alternative splicing represents one of the evolutionary forces underlying the increased structural complexity of metazoans. Brain and testes stand out as the organs that mostly exploit the potential of alternative splicing, thereby expressing the largest repertoire of splice variants. Herein, we will review organ-specific as well as common mechanisms underlying the high transcriptome complexity of these organs and discuss the impact exerted by this widespread alternative splicing regulation on the functionality and differentiation of brain and testicular cells.
Original language | English |
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Pages (from-to) | 480-489 |
Number of pages | 10 |
Journal | Cell Cycle |
Volume | 20 |
Issue number | 5-6 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- alternative splicing
- Brain
- neuron differentiation
- spermatogenesis
- testis
- transcriptomics
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology