Splicing regulation in brain and testis: common themes for highly specialized organs

Chiara Naro, Eleonora Cesari, Claudio Sette

Research output: Contribution to journalReview articlepeer-review

Abstract

Expansion of the coding and regulatory capabilities of eukaryotic transcriptomes by alternative splicing represents one of the evolutionary forces underlying the increased structural complexity of metazoans. Brain and testes stand out as the organs that mostly exploit the potential of alternative splicing, thereby expressing the largest repertoire of splice variants. Herein, we will review organ-specific as well as common mechanisms underlying the high transcriptome complexity of these organs and discuss the impact exerted by this widespread alternative splicing regulation on the functionality and differentiation of brain and testicular cells.

Original languageEnglish
Pages (from-to)480-489
Number of pages10
JournalCell Cycle
Volume20
Issue number5-6
DOIs
Publication statusPublished - 2021

Keywords

  • alternative splicing
  • Brain
  • neuron differentiation
  • spermatogenesis
  • testis
  • transcriptomics

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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