Spontaneous and cold pressor test-induced prostaglandin biosynthesis by human heart

Gian Gastone Neri Serneri, Gian Franco Gensini, Rosanna Abbate, Domenico Prisco, Pier Giorgio Rogasi, Sergio Castellani, Gian Carlo Casolo, Marzia Matucci, Fabio Fantini, Marisa Di Donato, Roberto Piero Dabizzi

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Abstract

To investigate prostaglandin biosynthesis by the heart, 21 patients undergoing cardiac catheterization and coronary angiography for congenital or acquired heart diseases other than coronary artery disease were investigated. Prostacyclin (as 6-keto-PGF), PGE2, PGF and TxA2 (as TxB2) were measured by specific radioimmunoassay in blood from coronary sinus, aorta, and a peripheral vein under resting conditions and following cold pressor test (CPT). PGF was always found undetectable. In resting conditions, no significant differences in plasma 6-keto-PGF, PGE2, or TxB2 concentrations were found among coronary sinus, aorta, and peripheral venous blood and no transcardiac gradient existed (mean: +0.4 ± 1.2 pg/ml for 6-keto-PGF, + 0.1 ± 0.6 pg/ml for PGE2, and -0.4 ± 9.9 pg/ml for TxB2). CPT was able to induce a significant increase in 6-keto-PGF and PGE2 concentration in blood from the different sampling sites and a significant transcardiac gradient was found following CPT (+11.6 ± 7.4 pg/ml for 6-keto-PGF (p <0.01) and +5.2 ± 3.6 pg/ml for PGE2 (p <0.001). TxB2 levels significantly increased in peripheral venous blood (from 18.3 ± 6.2 to 29.2 ± 20.3 pg/ml, p <0.05), but they did not increase either in coronary sinus (from 21.9 ± 9.7 to 22.9 ± 9.8 pg/ml) or in aorta (from 22.3 ± 4.7 to 19.1 ± 6.5 pg/ml). Present results indicate that a cardiocoronary prostacyclin and PGE2 synthesis is inappreclable under resting conditions but it becomes remarkable following sympathetic stimulation. On the contrary, no TxA2 cardiocoronary biosynthesis seems to occur in patients free from coronary artery disease.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalAmerican Heart Journal
Volume110
Issue number1 PART 1
DOIs
Publication statusPublished - 1985

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Neri Serneri, G. G., Gensini, G. F., Abbate, R., Prisco, D., Rogasi, P. G., Castellani, S., Casolo, G. C., Matucci, M., Fantini, F., Donato, M. D., & Dabizzi, R. P. (1985). Spontaneous and cold pressor test-induced prostaglandin biosynthesis by human heart. American Heart Journal, 110(1 PART 1), 50-55. https://doi.org/10.1016/0002-8703(85)90513-7