Spontaneous and griseofulvin-induced segregation for 8-azaguanine resistance in hybrids from a human heteroploid line

L. Larizza, G. Simoni, M. Stefanini, L. de Carli

Research output: Contribution to journalArticlepeer-review

Abstract

Griseofulvin (GF) treatment was found to increase segregation of the 8AG-sensitive parental type in hybrids produced between HGPRT- and HGPRT+ clonal derivatives of the human heteroploid line EUE. Continued platings in 8AG medium after a period of growth in medium without 8AG revealed the same degree of stability of the character both in the spontaneous and the induced segregants. Induced segregation rate (ISR), i.e., the ratio between the frequency of 8AG-resistant colonies from treated and untreated cells, showed a marked variation among different hybrids.

Original languageEnglish
Pages (from-to)405-409
Number of pages5
JournalExperimental Cell Research
Volume120
Issue number2
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cell Biology

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