Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia

Giovanni Del Poeta, Maria Ilaria Del Principe, Luca Maurillo, Francesca Maria Rossi, Francesco Buccisano, Emanuele Ammatuna, Cristina Simotti, Antonella Zucchetto, Gianfranco Catalano, Pietro Bulian, Antonio Bruno, Adriano Venditti, Paolo De Fabritiis, Valter Gattei, Sergio Amadori

Research output: Contribution to journalArticle

Abstract

In chronic lymphocytic leukemia (CLL), inhibition of spontaneous apoptosis determines a worse prognosis and increasing evidences show that disease progression relies also upon cycling CLL cells. We investigated bcl-2, as measure of apoptosis, and CD71, as measure of proliferation, by flow cytometry in 265 patients with CLL. Combining bcl-2 with CD71 values, we defined three subgroups: (1) bcl2-CD717; (2) bcl2+CD71+; and (3) bcl2+CD717 - or bcl2-CD71+. Both a shorter progression-free survival (PFS) and overall survival (OS) were observed in ZAP-70+ (p2 microglobulin (B2 -M) (p=0.003), bcl-2 (p=0.004), CD49d (p=0.001), and ZAP-70 (p2 -M (p=0.009) and bcl-2 (p=0.03) was confirmed within ZAP-70 negative patients. Bcl-2 and CD71 can be considered as interesting progression indicators, which should be validated in an independent cohort of patients, to take timely therapeutic decisions in CLL.

Original languageEnglish
Pages (from-to)95-106
Number of pages12
JournalLeukemia and Lymphoma
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Keywords

  • Bcl-2
  • CD71
  • CLL
  • Flow cytometry
  • Prognostic factors
  • ZAP-70

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Del Poeta, G., Del Principe, M. I., Maurillo, L., Rossi, F. M., Buccisano, F., Ammatuna, E., Simotti, C., Zucchetto, A., Catalano, G., Bulian, P., Bruno, A., Venditti, A., De Fabritiis, P., Gattei, V., & Amadori, S. (2010). Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia. Leukemia and Lymphoma, 51(1), 95-106. https://doi.org/10.3109/10428190903350421