Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia

Giovanni Del Poeta; Maria Ilaria Del Principe; Luca Maurillo; Francesca Maria Rossi; Francesco Buccisano; Emanuele Ammatuna; Cristina Simotti; Antonella Zucchetto; Gianfranco Catalano; Pietro Bulian; Antonio Bruno; Adriano Venditti; Paolo De Fabritiis; Valter Gattei; Sergio Amadori

doi:10.3109/10428190903350421

Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia

Giovanni Del Poeta, Maria Ilaria Del Principe, Luca Maurillo, Francesca Maria Rossi, Francesco Buccisano, Emanuele Ammatuna, Cristina Simotti, Antonella Zucchetto, Gianfranco Catalano, Pietro Bulian, Antonio Bruno, Adriano Venditti, Paolo De Fabritiis, Valter Gattei, Sergio Amadori

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

In chronic lymphocytic leukemia (CLL), inhibition of spontaneous apoptosis determines a worse prognosis and increasing evidences show that disease progression relies also upon cycling CLL cells. We investigated bcl-2, as measure of apoptosis, and CD71, as measure of proliferation, by flow cytometry in 265 patients with CLL. Combining bcl-2 with CD71 values, we defined three subgroups: (1) bcl2-CD717; (2) bcl2+CD71+; and (3) bcl2+CD717 - or bcl2-CD71+. Both a shorter progression-free survival (PFS) and overall survival (OS) were observed in ZAP-70+ (p2 microglobulin (B₂ -M) (p=0.003), bcl-2 (p=0.004), CD49d (p=0.001), and ZAP-70 (p2 -M (p=0.009) and bcl-2 (p=0.03) was confirmed within ZAP-70 negative patients. Bcl-2 and CD71 can be considered as interesting progression indicators, which should be validated in an independent cohort of patients, to take timely therapeutic decisions in CLL.

Original language	English
Pages (from-to)	95-106
Number of pages	12
Journal	Leukemia and Lymphoma
Volume	51
Issue number	1
DOIs	https://doi.org/10.3109/10428190903350421
Publication status	Published - Jan 2010

Keywords

Bcl-2
CD71
CLL
Flow cytometry
Prognostic factors
ZAP-70

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Del Poeta, G., Del Principe, M. I., Maurillo, L., Rossi, F. M., Buccisano, F., Ammatuna, E., Simotti, C., Zucchetto, A., Catalano, G., Bulian, P., Bruno, A., Venditti, A., De Fabritiis, P., Gattei, V., & Amadori, S. (2010). Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia. Leukemia and Lymphoma, 51(1), 95-106. https://doi.org/10.3109/10428190903350421

Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia. / Del Poeta, Giovanni; Del Principe, Maria Ilaria; Maurillo, Luca; Rossi, Francesca Maria; Buccisano, Francesco; Ammatuna, Emanuele; Simotti, Cristina; Zucchetto, Antonella; Catalano, Gianfranco; Bulian, Pietro; Bruno, Antonio; Venditti, Adriano; De Fabritiis, Paolo; Gattei, Valter; Amadori, Sergio.

In: Leukemia and Lymphoma, Vol. 51, No. 1, 01.2010, p. 95-106.

Research output: Contribution to journal › Article › peer-review

Del Poeta, G, Del Principe, MI, Maurillo, L, Rossi, FM, Buccisano, F, Ammatuna, E, Simotti, C, Zucchetto, A, Catalano, G, Bulian, P, Bruno, A, Venditti, A, De Fabritiis, P, Gattei, V & Amadori, S 2010, 'Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia', Leukemia and Lymphoma, vol. 51, no. 1, pp. 95-106. https://doi.org/10.3109/10428190903350421

Del Poeta, Giovanni ; Del Principe, Maria Ilaria ; Maurillo, Luca ; Rossi, Francesca Maria ; Buccisano, Francesco ; Ammatuna, Emanuele ; Simotti, Cristina ; Zucchetto, Antonella ; Catalano, Gianfranco ; Bulian, Pietro ; Bruno, Antonio ; Venditti, Adriano ; De Fabritiis, Paolo ; Gattei, Valter ; Amadori, Sergio. / Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia. In: Leukemia and Lymphoma. 2010 ; Vol. 51, No. 1. pp. 95-106.

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AU - Simotti, Cristina

AU - Zucchetto, Antonella

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AU - Bruno, Antonio

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