Spontaneous confabulations in amnestic-mild cognitive impairment due to Alzheimer’s disease: a new (yet old) atypical variant?

Carlo Abbate, Pietro Davide Trimarchi, Emanuela Rotondo, Silvia Inglese, Paola Nicolini, Paolo Dionigi Rossi, Beatrice Arosio, Daniela Mari

Research output: Contribution to journalArticlepeer-review

Abstract

Confabulation may be present in Alzheimer’s disease (AD), but usually it is not a primary feature of either its typical or atypical variants. In this report, we describe the case of an AD patient who showed an unusual and enduring neuropsychiatric phenotype characterized by early and prominent spontaneous confabulation. Surprisingly, such atypical AD presentation bears a striking resemblance to presbyophrenia, a subtype of dementia which was described at the beginning of the twentieth century and then sank into oblivion. In discussion, we speculate on the “return” of presbyophrenia as an unrecognized neuropsychiatric variant of AD and its possible neuroanatomical substrates.

Original languageEnglish
Pages (from-to)451-460
Number of pages10
JournalNeurocase
Volume22
Issue number5
DOIs
Publication statusPublished - 2016

Keywords

  • (Spontaneous) confabulations
  • Alzheimer’s disease (AD)
  • atypical variant AD
  • Mild Cognitive Impairment (MCI)
  • presbyophrenia

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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