Spontaneous diaphragmatic rupture following neoadjuvant chemotherapy and cytoreductive surgery in malignant pleural mesothelioma: A case report and review of the literature

Margherita Cattaneo, Paolo Mendogni, Francesco Damarco, Davide Tosi

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Diaphragmatic rupture (DR) is an acquired diaphragmatic defect that can cause herniation of abdominal organs into the chest. It is usually a trauma-related lesion, but rarely it can occur spontaneously. Every DR with abdominal herniation should be considered a surgical emergency. Presentation of case: A 61-year-old male patient, with previous exposure to asbestos, was diagnosed of Stage Ib malignant pleural mesothelioma (MPM). He underwent neo-adjuvant chemotherapy (three cycle of cisplatin-pemetrexed combination) and a cytoreductive surgery with pleurectomy/decortication. Post-operative course was characterized by prolonged air-leakage (PAL). After three months, during a follow-up CT-scan, a spontaneous diaphragmatic rupture (SDR) with gastric herniation was detected and treated by a laparascopic diaphragmatic repair and suture. Discussion: Spontaneous diaphragmatic rupture (SDR) is an extremely rare injury of the diaphragm (less than 1% of all DR). In this case, potential predisposing factors for SDR could be: presence of diaphragmatic “locus minoris resistentiae” due to thinning of the diaphragm and increase tissue fragility after neo-adjuvant chemotherapy and diaphragmatic pleural stripping; increased thoraco-abdominal pressure gradient due to PAL and residual pleural space. Thus, we confirmed the feasibility and safety of the laparoscopic approach. Conclusion: We highlight the multifactor etiopathology, the challenging diagnosis and the importance of a prompt treatment of SDR.

Original languageEnglish
Pages (from-to)S85-S87
JournalInternational Journal of Surgery Case Reports
Volume77
Issue numberSuppl.
DOIs
Publication statusPublished - 2020

Keywords

  • Case report
  • Diaphragmatic herniation
  • Malignant pleural mesothelioma
  • Spontaneous diaphragmatic rupture

ASJC Scopus subject areas

  • Surgery

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