Spontaneous embryonic loss following in vitro fertilization: Incidence and effect on outcomes

Giovanni B. La Sala, Giuseppe Nucera, Andrea Gallinelli, Alessia Nicoli, Maria Teresa Villani, Isaac Blickstein

Research output: Contribution to journalArticle

Abstract

Objectives The purpose of this study was to determine the early spontaneous loss rate in multiple pregnancies following assisted reproductive technology (ART). Study design Analysis of pregnancies following ART as related to the initial number of embryos and maternal age was performed. Results At least one spontaneous loss was observed in 47.0% (95% CI 29.8-64.9) of quadruplets, 59.3% (95% CI 48.2-69.8) of triplets, and 35.2% (95% CI 29.6-41.2) of twins. The increased loss rates in mothers ≥35 years was related to early twin pregnancies, but not to early triplet and quadruplet gestations. We could not find an effect of the starting number of embryos on either gestational age or birth weight characteristics. Conclusion Our observations did not identify a clear relation between early spontaneous loss of multiple gestations and either initial number of embryos or maternal age. Other factors might be involved in the outcome of ART multiple pregnancies.

Original languageEnglish
Pages (from-to)741-746
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume191
Issue number3
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Assisted Reproductive Techniques
Fertilization in Vitro
Multiple Pregnancy
Embryonic Structures
Maternal Age
Pregnancy
Incidence
Twin Pregnancy
Birth Weight
Gestational Age

Keywords

  • ART
  • Birth weight
  • Multiple births

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

Cite this

La Sala, G. B., Nucera, G., Gallinelli, A., Nicoli, A., Teresa Villani, M., & Blickstein, I. (2004). Spontaneous embryonic loss following in vitro fertilization: Incidence and effect on outcomes. American Journal of Obstetrics and Gynecology, 191(3), 741-746. https://doi.org/10.1016/j.ajog.2004.03.076

Spontaneous embryonic loss following in vitro fertilization : Incidence and effect on outcomes. / La Sala, Giovanni B.; Nucera, Giuseppe; Gallinelli, Andrea; Nicoli, Alessia; Teresa Villani, Maria; Blickstein, Isaac.

In: American Journal of Obstetrics and Gynecology, Vol. 191, No. 3, 09.2004, p. 741-746.

Research output: Contribution to journalArticle

La Sala, GB, Nucera, G, Gallinelli, A, Nicoli, A, Teresa Villani, M & Blickstein, I 2004, 'Spontaneous embryonic loss following in vitro fertilization: Incidence and effect on outcomes', American Journal of Obstetrics and Gynecology, vol. 191, no. 3, pp. 741-746. https://doi.org/10.1016/j.ajog.2004.03.076
La Sala, Giovanni B. ; Nucera, Giuseppe ; Gallinelli, Andrea ; Nicoli, Alessia ; Teresa Villani, Maria ; Blickstein, Isaac. / Spontaneous embryonic loss following in vitro fertilization : Incidence and effect on outcomes. In: American Journal of Obstetrics and Gynecology. 2004 ; Vol. 191, No. 3. pp. 741-746.
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