Spontaneous embryonic loss following in vitro fertilization: Incidence and effect on outcomes

Giovanni B. La Sala, Giuseppe Nucera, Andrea Gallinelli, Alessia Nicoli, Maria Teresa Villani, Isaac Blickstein

Research output: Contribution to journalArticlepeer-review


Objectives The purpose of this study was to determine the early spontaneous loss rate in multiple pregnancies following assisted reproductive technology (ART). Study design Analysis of pregnancies following ART as related to the initial number of embryos and maternal age was performed. Results At least one spontaneous loss was observed in 47.0% (95% CI 29.8-64.9) of quadruplets, 59.3% (95% CI 48.2-69.8) of triplets, and 35.2% (95% CI 29.6-41.2) of twins. The increased loss rates in mothers ≥35 years was related to early twin pregnancies, but not to early triplet and quadruplet gestations. We could not find an effect of the starting number of embryos on either gestational age or birth weight characteristics. Conclusion Our observations did not identify a clear relation between early spontaneous loss of multiple gestations and either initial number of embryos or maternal age. Other factors might be involved in the outcome of ART multiple pregnancies.

Original languageEnglish
Pages (from-to)741-746
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Issue number3
Publication statusPublished - Sep 2004


  • ART
  • Birth weight
  • Multiple births

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology


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