Spontaneous gasping produces carotid blood flow during untreated cardiac arrest

Giuseppe Ristagno, Wanchun Tang, Shijie Sun, Max Harry Weil

Research output: Contribution to journalArticle

Abstract

Objectives: Coincident with "agonal" gasping during cardiac arrest, there are prominent increases in stroke volumes even in the absence of chest compression. In the present study, we tested the hypothesis that gasps also increase carotid blood flow (CBF) during untreated cardiac arrest. Materials and methods: The tracheas of nine domestic male pigs, weighing 39 ± 2 kg, were intubated and animals were ventilated mechanically. Ventricular fibrillation (VF) was induced electrically and untreated for 5 min. Coincident with the onset of VF, mechanical ventilation was discontinued. The right femoral artery and vein were cannulated. Intrathoracic pressure (ITP) was measured with the aid of a balloon tipped catheter advanced into the esophagus for a distance of 35 cm. A transonic flowprobe was placed around the right common carotid artery for measurement of CBF. Results: Gasps increased in frequency during the first 4 min of untreated VF together with increases in CBF. The CBF produced by gasping averaged 220 ± 102 mL/min, which represented approximately 59% of a pre-cardiac arrest CBF. Significant increases in CBF were highly correlated with the decreases in ITP during the inspiratory phase of the gaspings (r = 0.78) and with the increases in aortic pressure during the expiratory phase of the gaspings (r = 0.76). Conclusions: Spontaneous gasps produce significant increases in CBF during untreated cardiac arrest. The present study therefore confirmed beneficial effects of gasping during cardiac arrest.

Original languageEnglish
Pages (from-to)366-371
Number of pages6
JournalResuscitation
Volume75
Issue number2
DOIs
Publication statusPublished - Nov 2007

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Keywords

  • Cardiac arrest
  • Carotid blood flow
  • Gasping
  • Intrathoracic pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nursing(all)

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