Spontaneous growth of colonies with mature T lineage phenotype from T-cell-depleted bone marrow precursors in a patient with a lymphoproliferative disorder of the large granular lymphocytes

V. Pistoia, E. F. Prasthofer, K. S. Zuckerman, C. E. Grossi

Research output: Contribution to journalArticlepeer-review

Abstract

Bone marrow cells from a patient with pancytopenia and a lymphoproliferative disorder of large granular lymphocytes (LGL) were cultured and tested for their hemopoietic colony-forming potential. Neither erythroid nor granulocyte-macrophage colony formation could be obtained from unfractionated, or LGL-depleted bone marrow cell preparations. However, a spontaneous growth of lymphoid colonies was observed after culturing LGL-depleted (T3-) bone marrow cell suspensions for 25 days. Pooled colonies expanded with recombinent interleukin-2 yielded a population composed predominantly of mature T cells (T3+, Leu 6+). These findings suggest that some (T3-) T cell precursors may mature in the bone marrow and that, in our patient, LGL may have exerted a suppressor effect on this maturational process.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalNatural Immunity and Cell Growth Regulation
Volume6
Issue number1
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology

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