Spontaneous improvement of optic pathway lesions in children with neurofibromatosis type 1

L. N. Rossi, F. Triulzi, C. Parazzini, M. M. Maninetti

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Two cases of spontaneous improvement of optic pathway lesions in neurofibromatosis type 1 are reported. At time of diagnosis the children were aged 21 and 32 months respectively; they have been followed by both MRI and clinical evaluation for 5 and 4 years. MRI findings of the first 19 months of follow-up for Case 1 have been described by us before. On MRI serial evaluation, Case 1 showed an almost complete normalization of the size of lesions and a resolution of enhancement, whereas Case 2 showed a slight decrease in the size of lesions and a resolution of enhancement. From the clinical point of view Case 1 showed a normalization of his clinical signs, whereas in Case 2, a visual improvement was only slight, if at all present. In Case 1, the clinical improvement seemed to follow the spontaneous regression of the lesions detected by MRI.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
Issue number4
Publication statusPublished - Aug 1999



  • MRI
  • Neurofibromatosis 1
  • Optic glioma
  • Optic pathway glioma

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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