Spontaneous infarction of pleomorphic adenoma: Report of a case simulating malignancy on fine-needle cytology sample

Franco Fulciniti, Nunzia Simona Losito, Gerardo Botti, Marco Manola, Franco Ionna

Research output: Contribution to journalArticle

Abstract

Ischemic or hemorrhagic infarction has been described as an uncommon but possible complication of fine-needle cytology sampling in numerous organs, more frequently the thyroid, the salivary glands, the breast, the lymph node, and the kidney. In these situations, infarction appears to be directly related to the vascular disturbances caused by needle sampling, though fine this latter might be. One case of a spontaneous infarction of a parotid pleomorphic adenoma in a 46-year-old lady is here described in which the cytopathologic findings, which were related to ischemic infarction, preceded fine-needle cytology sampling and mimicked malignancy. The cytopathologic picture showed a quizzical mixture of necrosis and inflammation coupled to hyperplastic changes of the acinar cells, oncocytic metaplasia, and atypical squamous metaplasia of extreme degree simulating high-grade epidermoid- or mucoepidermoid carcinoma. Due to the cytologically suggestive changes, a nerve-sparing radical parotidectomy was performed. The differential diagnostic problems encountered in this case are discussed together to the possible medical-legal implications originating from such striking atypias as to closely simulate malignancy.

Original languageEnglish
Pages (from-to)430-434
Number of pages5
JournalDiagnostic Cytopathology
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Pleomorphic Adenoma
Infarction
Needles
Cell Biology
Metaplasia
Neoplasms
Mucoepidermoid Carcinoma
Acinar Cells
Salivary Glands
Blood Vessels
Squamous Cell Carcinoma
Thyroid Gland
Breast
Necrosis
Lymph Nodes
Inflammation
Kidney

Keywords

  • Head and neck pathology
  • Ischemic changes following fine-needle sampling
  • Salivary gland pathology
  • Spontaneous infarction of pleomorphic adenoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Spontaneous infarction of pleomorphic adenoma : Report of a case simulating malignancy on fine-needle cytology sample. / Fulciniti, Franco; Losito, Nunzia Simona; Botti, Gerardo; Manola, Marco; Ionna, Franco.

In: Diagnostic Cytopathology, Vol. 38, No. 6, 06.2010, p. 430-434.

Research output: Contribution to journalArticle

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